Posterior blepharitis and dry eye are common disorders with meibomian gland dysfunction (MGD), a principal driver of their pathophysiology. Meibomian is increasingly prevalent in older populations contributory hormonal imbalances. The abnormal meibum MGD has been documented to have an excess cholesterol resultant disruption the lipid layer tear film. This leads film instability due inadequate t...

Capsaicin is the main pungent in chili peppers, one of the most commonly used spices in the world; its analgesic and anti-inflammatory properties have been proven in various cultures for centuries. It is a lipophilic substance belonging to the class of vanilloids and an agonist of the transient receptor potential vanilloid 1 receptor. Taking into consideration the complex neuro-immune impact of...

Recent findings demonstrate that human life is multiorganismal and microbe-host interactions play an important role in homeostasis disease. While some insights have been generated the gut, our understanding of skin still limited. We integrated metagenomic information from cutaneous microbes with transcriptome healthy, non-lesional lesional atopic psoriatic (n=272) to elucidate key pathways infl...

Cutaneous psoriasis improves with targeted pathway inhibition, but the homeostatic mechanisms that normally restrain chronic tissue inflammation remain incompletely understood. We single-cell profiled human psoriatic and normal skin resident memory T cell transcriptomes to reveal a gradated transcriptional program of coordinately regulated inflammation-suppressive genes. This program, which is ...

UV irradiation can injure the epidermis, resulting in sunburn, inflammation, and cutaneous tissue disorders. Previous studies demonstrate that EGFR keratinocytes be activated by UVB contributes to inflammation. Poly (ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme plays an essential role DNA repair under moderate stress. In this study, we set out understand how PARP-1 regulates irradiatio...