Cardiovascular disease (CVD) is the most common cause of morbidity and mortality worldwide and was responsible for 17.5 million deaths in 2012. This equals 31% of all deaths globally and is almost double the amount of cancer-related deaths (1). Although CVD encompasses a broad range of pathologic conditions, 80% of all CVD-related deaths are due to heart attacks and stroke (1). An important und...

BACKGROUND Cardiovascular diseases (CVD) are leading causes of mortality and morbidity among Indigenous people in New Zealand, Australia and Canada and are a major driver of the inequities in life expectancy between Indigenous and non-Indigenous people in these countries. Evidence-based pharmaceutical management of CVD can significantly reduce mortality and morbidity for persons diagnosed with ...

A wealth of evidence indicates a fundamental role for inflammation in the pathogenesis of cardiovascular disease (CVD), contributing to the development and progression of atherosclerotic lesion formation, plaque rupture, and thrombosis. An increasing body of evidence supports a functional role for complement activation in the pathogenesis of CVD through pleiotropic effects on endothelial and ha...

Epidemiological evidence indicates that high consumption of tomatoes and tomato-based products reduces the risk of chronic diseases such as CVD and cancer. Such potential benefits are often ascribed to high concentrations of lycopene present in tomato products. Mainly from the results of in vitro studies, potential biological mechanisms by which carotenoids could protect against heart disease a...

Abstract Introduction: The use of medicinal plants (MP) is increasing among the general population and patients with cardiovascular diseases (CVD). Simultaneous use of MP and cardiac medications can cause drug interactions and serious complications. Objective: This study aimed to determine the frequency of MP use and its related factors among patients with CVD. Materials and Methods: This c...

Purpose and Background/Significance: Cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM) are prevalent comorbid health conditions in adults, affecting roughly 65% of U.S. adult population, and are among the leading causes of premature disability and mortality. An underlying inflammatory mechanism is hypothesized in the development and progression of CVD. Poor T2DM control, depressi...

According to the World Health Organization, from 2014, cardiovascular diseases (CVD) are the number one cause of death worldwide. One of the key players in maintaining proper cardiovascular function is the endothelium, the inner layer of all blood vessels. This monolayer of cells on one hand serves as a barrier between blood and the surrounding tissue and on the other hand regulates many aspect...

Less than 2% of the genome encodes for proteins. Accumulating studies have revealed a diverse set of RNAs derived from the non-coding genome. Among them, long noncoding RNAs (lncRNAs) have garnered widespread attention over recent years as emerging regulators of diverse biological processes including in cardiovascular disease (CVD). However, our knowledge of their mechanisms by which they contr...