Introduction. Cyanide is one of the most rapidly acting poisons and therefore it can be important in cases suicide, homicide or accidental death. Nevertheless, cyanide intoxications are not common forensic practice. Case Report. We present a case Caucasian male, 63 years age, whose body was found lying bed his cottage by river. A gun on bedside table. Three glass bottles were under containing l...

Journal of Intensive Care Medicine 1987;2:260-78. 12 Hall AH, Rumack BH. Clinical toxicology of cyanide. Ann Emerg Med 1986;15:1067-74. 13 Stevenson RN, Kingswood C, Cohen SL, Vesey CJ. Cyanide and fire victims. Lancet 1988;ii: 1145. 14 Holland MA, Kozlowski LM. Clinical features and management of cyanide poisoning. Clin Pharm 1986;5:737-41. 15 Barillo DJ, Goode R, Rush BF, Reng Lang Lin, Freda...

Deaths due to smoke inhalation in fires are often due to poisoning by HCN. Rapid administration of antidotes can result in complete resuscitation of the patient but judicious dosing requires the knowledge of the level of cyanide exposure. Rapid sensitive means for blood cyanide quantitation are needed. Hydroxocyanocobinamide (OH(CN)Cbi) reacts with cyanide rapidly; this is accompanied by a larg...

Recently we had occasion to assay for lactate dehydrogenase (EC 1.1.1.27) in the presence of a large amount of potassium cyanide and were surprised to see a 10-fold increase in the enzyme activity when we used a method that depends on the measurement of NADH. At first we thought that we had made a significant observation.You can imagine our disappointment when we found that a control consisting...

Stroke is a leading cause of death and long-term disability. Methylene blue, a drug grandfathered by the Food and Drug Administration with a long history of safe usage in humans for treating methemoglobinemia and cyanide poisoning, has recently been shown to be neuroprotective in neurodegenerative diseases and brain injuries. The goal of this paper is to review studies on methylene blue in expe...

This review summarizes the findings from a retrospective study of 17,390 forensic autopsy cases of medicolegal investigations in Taiwan during the 1999-2008 period. Among this total, 1,874 cases involved illicit drugs and 750 involved household toxic chemicals. Rarely seen toxic substances, such as cyanide, corrosive poisons, ether, etc., were found in 6.4%percent; of homicide poisoning cases. ...

Rhodanese is the major detoxifying enzyme for cyanide and requires sulphur for its action. Allium cepa (Onion) is rich in organosulphur which may serve as an antidote for cyanide poisoning by supplying sulphur to the enzyme rhodanese. The possible effects of Allium cepa on rhodanese activity during cyanide toxicity was investigated in male Wistar rats. Sixty Wistar rats (150-180 g) were divided...