5-acyl-6-methyl-4-substituted-2-thioxo-1,2,3,4-tetrahydropyrimidines (1) were synthesized by cyclocondensation reaction between appropriate aldehyde, acetoacetate and thiourea in presence of aluminium chloride and hydrochloric acid which upon treatment with dimethylformamide and phosphorous oxychloride furnish the title compounds (2a-j). The structures of all title compounds have been confirmed...

A convenient and general method for the synthesis in 26-73% yields of a new series of 7-alkyl(aryl/heteroaryl)-2-amino-5-trifluoromethyl-1,8-naphthyridines from direct cyclocondensation reactions of 4-alkoxy-1,1,1-trifluoroalk-3-en-2-ones [CF₃C(O)CH=C(R¹)OR, where R¹ = H, Me, Ph, 4-MePh, 4-OMePh, 4-FPh, 4-BrPh, 4-NO₂Ph, 2-furyl, 2-thienyl and R = Me, Et] with 2,6-diaminopyridine (2,6-DAP), unde...

A series of macrocyclic imides and Schiff-bases have been prepared via the cyclocondensation of pyridine-2,6-dicarbonyl dichloride (1) with L-ornithine methyl ester to give the corresponding macrocyclic bisester 2. Treatment of 2 with hydrazine hydrate gave macrocyclic bisacid hydrazide 3, which was used as starting material. Condensation of bishydrazide 3 with diacid anhydrides or aromatic ald...

A new series of novel 4-(1H-benz[d]imidazol-2yl)-1,3-thiazol-2-amines 5a-d and 4-(1H-benz[d]imidazol-2yl)-3-alkyl-2,3-dihydro-1,3-thiazol-2-amine 8a-d has been synthesized by the cyclocondensation of 2-acetyl benzimidiazoles 4a-d and 2-bromo-1-(1-alkyl-1H-benzo[d]imidazol-2-yl)-1-ethanone 7a-d with thiourea respectively, and evaluated for their antibacterial and antifungal activity against clin...

Morpholinium hydrogen Sulphate as Brønsted acidic ionic liquid was used as an efficient and reusable catalyst for the onepot synthesis of 2,4,5-trisubstituted imidazoles that achieved by three component cyclocondensation of 1,2-dicarbonyl compound, aromatic or aliphatic aldehyde and ammonium acetate under thermal solvent-free conditions. The key advantages of this process are cost effectiveness...

This paper describes a modified method of preparation of a number of alpha-aryl-alpha-(pyridazin-3-yl)-acetonitriles via the C-arylation reaction of the corresponding carbanionsof phenylacetonitriles using 3-chloropyridazine derivatives. KOH and DMSO were used inthe deprotonation process, which made the reaction very simple and safe to perform.Nitriles were obtained in the hydrolysis reaction t...

A series of new 3-formyl coumarine (2) was synthesized in good yields by replacement of chlorine atom by 2 amines. In addition, 5-chromeno-pyrido[2,3-d]pyrimidine-4-yl derivatives (5,6) was synthesized by cyclocondensation of 6aminouracil, the respective ketones and 3-formyl coumarine (2) in one pot-synthesis. Also 2-S-nucleosides analogous of pyrido[2,3-d]-pyrimidines (12-15) was synthesized b...

Chagas disease is a so-called "neglected disease" and endemic to Latin America. Nifurtimox and benznidazole are drugs that have considerable efficacy in the treatment of the acute phase of the disease but cause many significant side effects. Furthermore, in the Chronic Phase its efficiency is reduced and their therapeutic effectiveness is dependent on the type of T. cruzi strain. For this reaso...

al-mcm-41 nanoreactors is found to be a remarkable efficient catalyst for one-pot multicomponent cyclocondensation of benzil, aniline or ammonium acetate and aromatic aldehydes for the synthesis of polysubstituted imidazoles under solvent-free conditions. the reaction was efficiently promoted by 10 mg nano-al-mcm-41 and the heterogeneous catalyst was recycled for four runs in this reaction with...