Despite its 3D porous structure, the pharmaceutical applications of cyclodextrin based cross-linked polymers are limited due to their structural irregularities. To address this issue, a template-directed strategy is used to obtain cubic micro and nano cyclodextrin cross-linked polymer (CD-cubes) from cyclodextrin metal organic frameworks in this study. The well-organized g-CDs in MOFs were cros...

A new approach to the synthesis of amphiphilic β-cyclodextrins has used 'click' chemistry to selectively modify the secondary 2-hydroxyl group. The resulting extended polar groups can be either polycationic or neutral PEGylated groups and these two amphiphile classes are compatible in dual cyclodextrin formulations for delivery of siRNA. When used alone with an siRNA, a cationic cyclodextrin wa...

Steviol glycosidesrebaudioside (reb) A, C and D have low aqueous solubilities. To improve their aqueous solubilities, inclusion complex of steviol glycosides, reb A, C and D and gamma cyclodextrin were prepared by freeze drying method and further characterized by means of differential scanning calorimetry, Fourier transform infrared spectroscopy and Raman spectroscopy. The effect of gamma cyclo...

Pioglitazone is an anti-diabetic drug in high blood sugar in patients with type 2 diabetes (non-insulin-dependent diabetes) which was belongs to poor aqueous solubility and bioavailable drug. By using β Cyclodextrin, the solubility and dissolution rate of Pioglitazone HCL can be enhanced and it was evaluated by synthesizing it into solid inclusion complexes in different ratio of drug: β cyclode...

Background: Paclitaxel is a potent anticancer drug that is effective against a wide spectrum of cancers. To overcome its bioavailability problems arising from very poor aqueous solubility and tendency to recrystallize upon dilution, paclitaxel is commercially formulated with co-solvents such as Cremophor EL® that are known to cause serious side effects during chemotherapy. Amphiphilic cyclodext...

One of the methods to enhance bio-accessibility of drugs like Acridone and its oxime is toform inclusion complexes with β-cyclodextrin. The formation of such complexes has beenconfirmed by changes in spectral characteristics and melting point data. The aqueous phasesolubility studies reveal 1:1 stoichiometry between the compound and, β-cyclodextrin. The studyof thermodynamic parameters like ΔG,...

The complex-forming abilities of a water-soluble ƒÀ-cyclodextrin-epichlorohydrin polymer (CDPS) and two different molecular weight fractions of CDPS were studied and compared with those of ƒÀ-cyclodextrin (ƒÀ3-CyD) and dimethyl-ƒÀ-cyclodextrin (DM-ƒÀ-CyD). CDPS was separated into two main fractions by gel chromatography. CDPS and its fractions formed inclusion compounds with several drugs and t...

A multidentate ligand is bonded to cyclodextrins by the reaction of diethylenetriaminepentaacetic dianhydride with 6-monoand 2-mono(ethylenediamine) derivatives of cyclodextrin. Adding Dy(II1) to the cyclodextrin derivatives enhances the enantiomeric resolution in the IH N M R spectra of carbinoxamine maleate, doxylamine succinate, pheniramine maleate, propranolol hydrochloride, and tryptophan....

The employment of cyclodextrin host-guest complexation to construct supramolecular assemblies with an emphasis on polymer networks is reviewed. The main driving force for this supramolecular assembly is host-guest complexation between cyclodextrin hosts and guest groups either of which may be discrete molecular species or substituents on a polymer backbone. The effects of such complexation on p...

Encapsulation makes the difference!. A β-cyclodextrin-based diphosphane ligand with metal confining properties is key in stabilization of heteroleptic Cu(I) complexes. In their Research Article (e202214638), Nicola Armaroli, Béatrice Delavaux-Nicot, Jean-François Nierengarten, Dominique Armspach et al. show how encapsulation metal-bound diimine moiety cyclodextrin cavity influences electronic p...