Seven new oxime-based acetylcholinesterase reactivators were compared with three currently available ones (obidoxime, trimedoxime, HI-6) for their ability to lessen cholinesterase inhibition in blood and brain of cyclosarin-treated rats. Oximes were given at doses of 5% their LD(50) along with 21 mg/kg atropine five min before the LD(50) of cyclosarin (120 ug/kg) was administered. Blood and bra...

The reactivating and therapeutic efficacy of two combinations of oximes (HI ‐6 + trimedoxime and HI ‐6 + K203) was compared with the effectiveness of antidotal treatment involving single oxime (hi ‐6, trimedoxime, K203) using in vivo methods. In vivo determined percentage of reactivation of cyclosarin ‐inhibited blood and tissue acetylcholinesterase in poisoned rats showed that the reactivating...

In this report, we describe a new method for the synthesis of densely functionalized 2(1H)-pyrazinones. Treatment of mesoionic 1,3-oxazolium-5-olates with carbanions derived from activated methylene isocyanides (p-toluenesulfonylmethyl isocyanide (TosMIC) and ethyl isocyanoacetate) causes a novel ring transformation affording 2(1H)-pyrazinones in moderate to high yields. The cytotoxicity and an...

The first nickel-catalyzed method for the borylation of carbon-hydrogen bonds in arenes and indoles is described. The use of an N-heterocyclic carbene ligand is essential for an efficient reaction, with an N-cyclohexyl-substituted derivative being optimal. This method is readily applied to the gram scale synthesis of 2-borylindole.

Reactions of [Pt(PCy(3))(2)] (Cy = cyclohexyl) with group 12 metal dihalides have afforded the novel metal only Lewis pair (MOLP) complexes, [(Cy(3)P)(2)Pt→MX(2)] (M = Zn or Cd, X = Br or I), or the oxidative addition product, trans-[(Cy(3)P)(2)(I)PtHgI]. The zinc complex represents the first MOLP to contain an unsupported Pt→Zn linkage.

In the title compound, [Sn(C(6)H(11))(2)(C(19)H(14)N(2)O(3))], the Sn(IV) atom is O,N,O' chelated by the deprotonated Schiff base ligand and exists in a cis-trigonal-bipyramidal environment, completed by the two cyclohexyl ligands.

Directed evolution of Pseudomonas aeruginosa lipase by the use of combinatorial active site saturation test (CAST) criteria provided a highly enantioselective mutant (Leu162Phe) for kinetic resolution of an axially chiral allene, p-nitrophenyl 4-cyclohexyl-2-methylbuta-2,3-dienoate (E=111); the high enantioselectivity of the Leu162Phe mutant was rationalized by pi-pi stacking.

In the title compound, C(18)H(16)Br(2)O(2), the dihedral angle between the aromatic rings is 35.55 (17)° and the cyclohexyl ring adopts a chair-like conformation. In the crystal, molecules are linked by van der Waals forces.

Using highly stable, readily accessible, and recyclable 2-(2-hydroxyprop-2-yl)cyclohexyl-substituted arylsilanes activated by a mild carbonate base, nickel-catalysed silicon-based aryl-aryl cross-coupling reaction proceeds for the first time with inexpensive aryl chlorides and tosylates in a highly chemoselective manner.