The freezing of the cooperative reorientational motions in orientationally disordered (OD) molecular crystals marks the so-called “glassy” transition, which may be considered a lower-dimensional version of the structural glass transition. While structural glasses display both positional and orientational disorder, in fact, in orientational glasses the disorder involves exclusively the orientati...

Little information is available on the environmental occurrence and ecotoxicological effects of pharmaceutical gestagens released in the aquatic environment. Since eighteen different gestagens were found to be used in France, preliminary exposure and hazard assessment were done. Predicted environmental concentrations (PECs) suggest that if parent gestagens are expected to be found in the ng l(-...

The aim of the present study was to evaluate the effects of three different anti-androgenic drug-therapy regimens, Diane 35 (cyproterone acetate (CPA) [2 mg] and ethinyl estradiol [35 microg]) plus CPA, Diane 35 plus spironolactone, and spironolactone alone, in patients with hirsutism. In this prospective, randomized clinical study, 79 subjects with idiopathic hirsutismus were studied. The pati...

The voltammetric behaviour of cyproterone acetate (CPA) was studied using direct current (DCt) and differential pulse polarography (DPP). The drug manifests cathodic waves over the pH range of 4-11.8. In Britton-Robinson buffer (BRb) of pH 10, the diffusion current-concentration relationship was found to be rectilinear over the range 3.2-32 μg/mL and 0.5-14 μg/mL using DCt and DPP modes, respec...

Cyproterone acetate (CPA), a synthetic progestin recently found to induce genotoxic effects in hepatocytes from female rats and from humans of both genders, and two structural analogues, chlormadinone acetate (CMA) and megestrol acetate (MGA), have been compared for their capacity to induce DNA repair synthesis as measured by quantitative autoradiography. Exposure of primary human hepatocytes f...

The psychological symptoms assessed with a validated psychometric scale, SCL-90, were significantly higher in postmenopausal women (PMW; 60 subjects) than in premenopausal women (20 subjects). In the same PMW, the activity of the dopaminergic system, assessed with the PRL response to the dopamine-blocking agent sulpiride, was significantly lower than that in premenopausal women. During a period...

The aim of the study was to test the effect of antiandrogen, cyproterone acetate (CA) on the antler cycle in the red deer (Cervus elaphus). CA was administered to three adult red deer stags (Edward, Fuks and Gacek) in weekly intervals. Edward and Fuks were given 600 mg + 600 mg of CA, whereas Gacek was given 600 mg + 300 mg. CA was injected during the hard antler phase: in mid-October (Edward),...

Gaussian scale space permits one to compute image derivatives. The limitation to some finite order is not inherent in the paradigm itself (Gaussian blurred functions are always smooth), but is caused by the interplay of (at least) two external factors. One is the ratio of the Gaussian scale parameter versus the atomic scale that limits physically or perceptually meaningful sizes (e.g. pixel siz...

Two studies were performed to evaluate the effects of dried distillers grains with solubles (DDGS) on the lactational performance of dairy cows. The intent of experiment 1 was to evaluate the effects of feeding increasing concentrations of DDGS on the feed intake and production of Holstein dairy cows. Twenty multiparous Holstein cows averaging 76 +/- 24 d in milk and 638 +/- 68 kg of body weigh...