Background: Mixed chimerism (MC) frequently occurs in patients with severe aplastic anemia (SAA) after allogeneic hematological stem cell transplantation (allo-HSCT).Methods A retrospective study on 287 SAA who underwent allo-HSCT between October 2012 and January 2020 was conducted to explore the outcomes, risk factors treatment options for MC. Among AA excluded Fanconi (FA), Congenital dyskera...

Myelodysplastic syndromes are clonal disorders with morphological dysplasia, a variable degree of cytopenia and risk transformation to acute myeloid leukemia. Prognosis is very defined by blast count, cytopenia, cytogenetics more recently somatic mutations, IPSS or revised score being the most widely used assess disease risk. HSCT remains only curative treatment date, high-risk patients obtaini...

Background Cytopenia is a frequent complication among HIV-infected patients who require hospitalization. It can have negative impact on the treatment outcomes for these patients. However, by leveraging machine learning techniques and electronic medical records, predictive model be developed to evaluate risk of cytopenia during hospitalization in HIV Such crucial designing more individualized ev...

Hematopoiesis is one of the most radiosensitive system of the human organism. The intensity of effects induced by chronic radiation exposure depends on dose and dose rate. Completeness and duration of hematopoiesis recovery are determined by the intensity of changes occurring during the maximal radiation exposure and on individual radiosensitivity. Long-term (months, years) irradiation even dur...

A young woman in maintenance therapy for acute lymphoblastic leukemia in second complete remission developed fever and a skin rash associated with severe anemia, neutropenia and erythroblastopenia. A complete recovery was obtained in 4 weeks' time after red cell transfusion, i.v. immunoglobulin and withdrawal of the maintenance chemotherapy. Parvovirus B19 infection was demonstrated by detectio...