Saxagliptin (SAX) is an oral drug that a hypoglycemic (between anti-diabetic agent) dipeptidyl peptidase-4 inhibitor. In this study, cytotoxic, genotoxic effects and DNA damage of SAX on human lymphocytes were investigated. For purpose, Single Cell Gel Electrophoresis (SCGE), Micronucleus (MN) Mitotic Index (MI) tests used. Based the daily doses SAX, 0.017, 0.035, 0.07, 0.14 µg/mL concentratio...

background and objectives: iran owns a rich and prestigious heritage of medicinal herbs but the majority of these plants have not yet undergone chemical, pharmacological and toxicological studies. in the present study some species form northern parts of iran were evaluated for cytotoxicity. methods: sixteen medicinal plants were extracted with methanol and screened for their cytotoxic activitie...