DNA double-strand break repair involves phosphorylation of histone variant H2AX ('γH2AX'), which accumulates in foci at sites of DNA damage. In current models, the recruitment of multiple DNA repair proteins to γH2AX foci depends mainly on recognition of this 'mark' by a single protein, MDC1. However, DNA repair proteins accumulate at γH2AX sites without MDC1, suggesting that other 'readers' of...

Leakage of cellular enzymes into the plasma is a clear indication of cell damage. When liver plasma membrane is damaged, a variety of enzymes normally located in the cytosol are released into the blood stream and their estimation is a quantitative marker for the extent of damage. The cytoprotective effect of Semecarpus anacardium was evaluated in rats that were rendered diabetic by administrati...

Rail grinding is a maintenance task performed in the field to return it profile and/or remove damage, however, can affect surface integrity of rail. In this paper, damage resistance three different ground rails (R260, R350HT and R400HT) was evaluated. samples were using same parameters low-traffic line field. The rail metallurgy then examined, white etching layer (WEL) formation wear rolling co...

Most of the existing personalization systems such as content recommenders or targeted ads focus on individual users and ignore the social situation in which the services are consumed. However, many human activities are social and involve several individuals whose tastes and expectations must be taken into account by the system. When a group profile is not available, different profile aggregatio...

concrete bridge deck damage detection by measurement and monitoring variables related to vibration signatures is one of the main tasks of any bridge health monitoring system (bhms). generally damage puts some detectable/discoverable signs in the parameters of bridge vibration behavior. however, differences between frequency and mode shape before and after damage are not remarkable as vibration ...

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the density and polarization profiles of the dipolar hard ellipsoids confined between hard walls are studied using the density functional theory (dft). the hyper-netted chain (hnc) approximation is used to write excess grand potential of the system with respect to the bulk value. the number density is expanded up to zero and first order in polarization to find the results. for the zero order in...