نتایج جستجو برای: danon
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The complex of Vacuolar Protein Sorting 34 and 15 (Vps34 and Vps15) has Class III phosphatidylinositol 3-kinase activity and putative roles in nutrient sensing, mammalian Target Of Rapamycin (mTOR) activation by amino acids, cell growth, vesicular trafficking and autophagy. Contrary to expectations, here we show that Vps15-deficient mouse tissues are competent for LC3-positive autophagosome for...
BACKGROUND Mutations in the gamma2 subunit (PRKAG2) of AMP-activated protein kinase produce an unusual human cardiomyopathy characterized by ventricular hypertrophy and electrophysiological abnormalities: Wolff-Parkinson-White syndrome (WPW) and progressive degenerative conduction system disease. Pathological examinations of affected human hearts reveal vacuoles containing amylopectin, a glycog...
This essay is intended as an introduction to “French enunciative narratology” or the theory thus termed on the basis of a certain number of criteria presented in the introduction: the fact that it is produced by linguists; the fact that it aims to remedy the shortcomings of Genettian narratology in the domain of linguistics; the fact that it refers to the work of enunciative linguistics, applie...
MATERIALS AND METHODS Stock cultures of T. aceti were grown axenically at 27 °C in a liquid medium described by Castillo and Krusberg (2) . Female nematodes from two cultures were examined, one of which had been maintained at East Wareham for 4 yr and the other obtained from the Department of Cell Physiology, Boston Biomedical Research Institute . Age at sacrifice for electron microscopy was de...
An autopsy and microscopic analyses of a 74-year-old female with a clinical history of cardiac hypertrophy and hypertension disclosed a pronounced distension of lysosomal compartment with signs of excessive autophagocytosis, predominantly in cardiomyocytes, hepatocytes and smooth muscle cells of the small intestine. The histological storage pattern did not correspond to the usual changes seen i...
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