Current models suggest that genomic instability is crucial in the accumulation of the multiple alterations required for tumorigenesis. However, the nature of the initial damage responsible for the origin of genomic instability remains poorly understood. In this investigation we demonstrate that the nucleotide analog 2,6-diaminopurine (DAP) can be used to induce highly focused damage to the larg...

BACKGROUND 3,4-diaminopyridine (3,4-DAP), a potassium (K+) channel blocker, improves fatigue and motor function in multiple sclerosis (MS). Although it was thought to do so by restoring conduction to demyelinated axons, recent experimental data show that aminopyridines administered at clinical doses potentiate synaptic transmission. OBJECTIVE To investigate motor cerebral activity with fMRI a...

Application of a preplant or preemergence glyphosate burndown is routine in most no-tillage production systems of annual crops, however, time of application may influence overall weed control and grain yield. Six field trials were conducted over a three-year period (2008, 2009 and 2010) near Ridgetown, Ontario, Canada to determine the effect of glyphosate burndown application timing in glyphosa...

PURPOSE Death-associated protein (DAP)-kinase gene is frequently inactivated by promoter hypermethylation in cancer. The aim of this study was to evaluate the promoter methylation status of the DAP-kinase gene in nasopharyngeal carcinoma (NPC). EXPERIMENTAL DESIGN The methylation status was evaluated by methylation-specific PCR (MSP). Thirty-two NPC biopsy specimens, plasma and buffy coat of ...

For 318 patients in 8 different Belgian hospitals, the entire skin-dose distribution was mapped using a grid of 70 thermoluminescence dosimeters per patient, allowing an accurate determination of the maximum skin dose (MSD). Dose-area product (DAP) values, exposure parameters and geometry, together with procedure, patient and cardiologist characteristics, were also registered. Procedures were d...

2,6-Diaminopurine (DAP) is an analogue of adenine which can be converted to nucleotides that serve as substrates for incorporation into nucleic acids by polymerases in place of (d)AMP. It pairs with thymidine (or uracil), engaging in three hydrogen bonds of the Watson-Crick type. The result of DAP incorporation is to add considerable stability to the double helix and to impart other structural ...

A research study entitled "Effect of Diammonium Phosphate (DAP) on flowers and bulb production of Tulip’s cultivars" was conducted at Ornamental Nursery, Department of Horticulture, The University of Agriculture Peshawar-Pakistan. The results of the experiment showed that there was a significant effect on number of days to flowering (108.0) and leaf length (22.50 cm), when applied DAP at the ra...

OBJECTIVE To assess whether a novel 'direct access pathway' (DAP) for the management of high-risk non-ST-elevation acute coronary syndromes (NSTEACS) is safe, results in 'shorter time to intervention and shorter admission times'. This pathway was developed locally to enable London Ambulance Service to rapidly transfer suspected high-risk NSTEACS from the community to our regional heart attack c...

In the present study effects of production history on tuber sprout, root, stem development and crop yield of seed potato cultivars Fambo and Van Gogh were investigated in the High Grade Area of Finland (64.9 N, 25.4 E). The haulms of seed potatoes were destroyed at the time of flowering (50 days after planting, DAP), three weeks after flowering (75 DAP) and as a control the haulm was left to na...

Ductal adenocarcinoma of the prostate was initially described in 1967 by Melicow and Patcher. It was given the erroneous name endometrioid carcinoma, however, further studies confirmed the prostatic origin of this tumor. Currently DAP is classified as a histological variant of prostatic carcinoma. Compared with "classic" acinar carcinoma of the prostate, DAP is a rare histological finding. It's...