The emergence of antibody-drug conjugates (ADC), such as brentuximab vedotin and ado-trastuzumab emtansine, has led to increased efforts to identify new payloads and develop improved drug-linker technologies. Most antibody payloads impart significant hydrophobicity to the ADC, resulting in accelerated plasma clearance and suboptimal in vivo activity, particularly for conjugates with high drug-t...

This paper discusses the potential use of terahertzfrequency spectroscopy as a technique for the remote detection of biological warfare agents. Here, design studies are presented for a differential-absorption-radar (DAR) approach that utilizes the spectral signatures of Bacillus (B.) subtillus spores within the terahertz (THz) regime as the detection mechanism. The signature data used in these ...

FACTORS INFLUENCING QUALITY OF HEALTH MANAGEMENT INFORMATION SYSTEM (HMIS) DATA THE CASE OF KINONDONI DISTRICT IN DAR ES SALAAM REGION, TANZANIA Daudi O. Simba and Mughwira A. Mwangu

Mosquito larvae live in dynamic aqueous environments, which can fluctuate drastically in salinity due to environmental events such as rainfall and evaporation. Larval survival depends upon the ability to regulate hemolymph osmolarity by absorbing and excreting ions. A major organ involved in ion regulation is the rectum, the last region for modification of the primary urine before excretion. Th...

Soziale und gesellschaftliche Probleme, wie Klimawandel oder Luftverschmutzung, stellen wichtige Themen dar, der sich sowohl die Politik als auch die breite Masse der Bevölkerung annehmen sollte. 1 Einleitung

uring the reign of the fourth Qajar king, Naser-ad-Din Shah (who reigned from 1848–1896), the Chief Minister, Amir Kabir, was involved in modernization of Iran. He founded the first modern higher educational institute in Iran the so called “Dar al-Fonun” (House of Techniques) in 1851. One of the subjects taught there was medicine; now, it is considered a major step in promulgation of modern med...

This paper presents a new technology and a systematic approach for disaster response and recovery of Critical Physical Infrastructures (CPIs). Our suggested approach is based on using a Mobile Workstation Chariot (MWC) assembled on Segway personal transporter which supports both horizontal and vertical real-time visual data capture and transmission flow, first responders and civil engineers can...