The relationship between the microbiota profile and exposure to stress is not well understood. Therefore, we used a rat model of unpredictable chronic mild (UCMS) investigate this relationship. Depressive-like behaviors were measured in Female Sprague Dawley rats using sucrose preference test Porsolt swim test. Anxiety-like with light–dark box Fecal corticosterone, cecal (composition organic ac...

Foliation of the cerebella of Sprague-Dawley rats (strain Han:SPRD) is more advanced than in Wistar rats (strain Chbb:THOM). The differences expressed as length of the granular layer in median sections were significant in lobules VIa, VIII, IX and X. The length of the other vermian lobules is generally higher in the former strain. With regard to the volume of the granular layer, the situation i...

Efforts have been made to find a better therapeutic approach with fewer side effects in treating chronic obstructive pulmonary disease (COPD). This study investigated the effect of Buyuan decoction (BYD) on autophagy COPD rats. An experimental model Sprague-Dawley rats was established by lipopolysaccharide (LPS) injection and cigarette smoke exposure. Rats were randomly allocated into blank con...

Recently a new rat model for type 2 diabetes the Zucker diabetic Sprague-Dawley (ZDSD/Pco) was created. In this study we sought to characterize the development of diabetic neuropathy in ZDSD rats using age-matched Sprague-Dawley rats as a control. Rats were examined at 34 weeks of age 12 weeks after the onset of hyperglycemia in ZDSD rats. At this time ZDSD rats were severely insulin resistant ...

Caloric restriction (CR) and metabolic glucoprivation affect spontaneous physical activity (SPA), but it's unknown whether these treatments similarly affect SPA in selectively bred obesity-prone (OP) and -resistant (OR) rats. OR rats have greater basal SPA and are more responsive to treatments that modulate SPA, such as orexin A administration. We hypothesized that OR rats would be more sensiti...

The survival time of rats with 7 , l2-dimethylbenzanthra cene-induced tumors is significantly increased by treatment with the combination of the cyclic imide l-(morpholino methyl)-4-phthalimido-piperidindione-2 , 6 and drostanolone propionate (2a-methyl dihydrotestosterone propionate). In long-term treatment the antitumor activity, determined by the number of the tumor centers, is likewise sign...

The transgenic rat TGR(mRen-2)27, in which the Ren-2 mouse renin gene is transfected into the genome of the rat, develops severe hypertension with high adrenal renin and low kidney renin. These animals express both mouse and rat renin. To investigate the cause of hypertension in the TGR rat, we compared the kinetics of mouse renin acting on mouse and rat angiotensinogens. The optimum pH of the ...

background: there is yet a dearth of literature on the antifertility effect of momordica charantia on the male reproductive system. the aim of this study was to determine the effect of graded oral doses of methanolic seed extract of momordica charantia on the histology of prostate gland and seminiferous tubules of rats. methods: forty male sprague-dawley rats, weighing 176±7 g were assigned ran...