BACKGROUND Human dopamine β-hydroxylase (DBH) is an important therapeutic target for complex traits. Several single nucleotide polymorphisms (SNPs) have also been identified in DBH with potential adverse physiological effect. However, difficulty in obtaining diffractable crystals and lack of a suitable template for modeling the protein has ensured that neither crystallographic three-dimensional...

The miombo woodland is the most extensive dry forest in the world, with the potential to store substantial amounts of biomass carbon. Efforts to obtain accurate estimates of carbon stocks in the miombo woodlands are limited by a general lack of biomass estimation models (BEMs). This study aimed to evaluate the accuracy of most commonly employed allometric models for estimating aboveground bioma...

Epilepsy is a disease of neuronal hyperexcitability, and pharmacological and genetic studies have identified norepinephrine (NE) and neuropeptide Y (NPY) as important endogenous regulators of neuronal excitability. Both transmitters signal through G-protein-coupled receptors, are expressed either together or separately, and are abundant in brain regions implicated in seizure generation. NPY kno...

A prospective study was undertaken to evaluate the relative contribution of changes in sympathetic nervous system activity, as reflected by changes in dopamine-beta-hydroxylase (DBH) activity, to the pathogenesis of oral contraceptive-induced hypertension. Precontraceptive and serial post contraceptive determinations of blood pressure, plasma renin activity (PRA), DBH activity, and changes in b...

Background and aims Corticostriatal-limbic neurocircuitry, emotional and motivational processing, dopaminergic and noradrenergic systems and genetic factors have all been implicated in pathological gambling (PG). However, allelic variants of genes influencing dopaminergic and noradrenergic neurotransmitters have not been investigated with respect to the neural correlates of emotional and motiva...

The influence of sympathetic nervous activity on cerebral circulation and cerebrovascular CO2 reactivity was investigated through inhibition of dopamine beta-hydroxylase (DBH). A PO2 electrode, a PCO2 electrode and a plate-type thermocouple-flowmeter were placed on the pial surface of the cat brain. Cerebrocortical PO2, PCO2, cerebrocortical blood flow and arterial blood pressure were continuou...

Noradrenergic stimulation increases progesterone, oxytocin and prostaglandins in the bovine luteal tissue. Better understanding of noradrenaline (NA) role in bovine the corpus luteum (CL) can advance our current knowledge on the regulatory mechanism of CL function. The present study was conducted to explore the source of noradrenaline and further to investigate whether nerve growth factor (NGF)...

Attention-deficit hyperactivity disorder (ADHD) is a common disorder of the school-age population. ADHD is familial, and genetic studies estimate heritability at 80%-90%. The aim of the present study was to investigate the association between the genetic type and alleles for the dopamine beta-hydroxylase (DBH) gene in Korean children with ADHD. The sample consisted of 142 ADHD children and 139 ...

Dena Biosphere Reserve located in Iran and is a 550 Biosphere Reserve in the worlds. This research was investigated in the two protected and non-protected areas, in a Dena Biosphere Reserve, Kohkeloye va Boyrahmad province, and central zagros forest, southwest of Iran. Inventory methods designed by systemetic-randomaiz method by use the rectangular plots that were 15×30 meters in the 100×100 m ...

ABO blood groups have been studied for associations with personality traits with no scientific consensus of positive findings. Because of previously known variations in population frequency distributions of ABO blood groups and newly discovered single nucleotide polymorphisms in ABO gene in the human genome project, associations of personality traits and health risks with ABO blood groups conti...