Case report A 52-year-old HIV-1 positive Caucasian male started zidovudine (AZT), lamivudine, nelfinavir in 1999 at a CD4-cell count of 210/μL. In July 2007 treatment was switched because of viral blips to atazanavir, ritonavir, tenofovir, emtricitabine and didanosine (250 mg). Within one year his CD4-cell count declined from 1140 to 140/μL despite complete virological suppression [1]. Renal cl...

INTRODUCTION Although lower extremity deep vein thrombosis (DVT) is a common complication after an acute stroke, there is little local data documenting this condition in stroke patients undergoing rehabilitation. The purpose of this study was to determine the frequency and risk factors of DVT in ischaemic stroke patients admitted to a rehabilitation unit. METHODS This was a prospective observ...

For data-independent acquisition by means of sequential window acquisition of all theoretical fragment ion spectra (SWATH), a reference library of data-dependent acquisition (DDA) runs is typically used to correlate the quantitative data from the fragment ion spectra with peptide identifications. The quality and coverage of such a reference library is therefore essential when processing SWATH d...

Elastic light scattering by mature red blood cells (RBCs) was theoretically and experimentally analyzed by use of the discrete dipole approximation (DDA) and scanning flow cytometry (SFC), respectively. SFC permits measurement of the angular dependence of the light-scattering intensity (indicatrix) of single particles. A mature RBC is modeled as a biconcave disk in DDA simulations of light scat...

The lytic bacteriophage T4 uses multiple mechanisms to initiate the replication of its DNA. Initiation occurs predominantly at replication origins at early times of infection, but there is a switch to genetic recombination-dependent initiation at late times of infection. The T4 insertion-substitution system was used to create a deletion in the T4 dda gene, which encodes a 5'-3' DNA helicase tha...

Stereo-specific perturbation of the IgE-receptor (shown in previous studies) produces a monophasic rise in cyclic AMP that peaks at 15 s and a depletion of cyclic AMP-dependent protein kinase that plateaus at 30-60 s. The previously observed linear relationship between the attenuation in the monophasic rise in cyclic AMP and the quantity of mediator release in the presence of incremental concen...

In this article, we study decentralized convex constrained optimization problems in networks. We focus on the dual averaging-based algorithmic framework that is well-documented to be superior handling constraints and complex communication environments simultaneously. Two new averaging (DDA) algorithms are proposed. first one, a second-order dynamic average consensus protocol tailored for DDA-ty...

We report improvements in complex conjugate gradient algorithms applied to the discrete dipole approximation (DDA). It is shown that computational time is reduced by using the BiCGSTAB version of the CG algorithm, with diagonal left preconditioning.

Background: The widespread application of omics technologies in the past two decades has significantly expanded our knowledge cancer biology. Proteins act as link between genetic code and phenotype can better reflect dynamic state a cell. With rapid advances field proteomics, especially label-free proteomics quantification technology powered by LC-MS/MS, it is now routine to characterize quanti...