knowledge about the clinical significance of v-raf murine sarcoma viral oncogene homolog b1 ( braf ) mutations in colorectal cancer (crc) is growing. braf encodes a protein kinase involved with intracellular signaling and cell division. the gene product is a downstream effector of kirsten ras 1( kras ) within the ras/raf/mapk cellular signaling pathway. evidence suggests that braf mutations, li...

introduction: malaria is a protozoal disease, transmitted to humans by female anopheles mosquito bite. plasmodium falciparum, compared to other kinds of plasmodium, causes more severe malaria and is associated with a higher mortality rate. annually, one to three million deaths occur due to malaria, especially by p. falciparum. case presentation: in this report, we introduce an iranian patient s...

background: lactic acidosis in cardiac surgical patients is a manifestation of systemic inflammation and excess pro-inflammatory cytokine production. this investigation was designed to integrate basic concepts about lactate acidosis with a clinically used of serum lactate in patients under coronary artery bypass surgery (cabg) by on pump method. methods: from august to september 2012, 15 patien...

We consider a network of devices, such as generators, fixed loads, deferrable loads, and storage devices, each with its own dynamic constraints and objective, connected by AC and DC lines. The problem is to minimize the total network objective subject to the device and line constraints over a time horizon. This is a large optimization problem with variables for consumption or generation for eac...

The autonomy of various subsystems in complex real-time distributed computer systems (DCS's) is a highly desired attribute. Highly autonomous subsystems enable concurrent and largely independent testing/verification and maintenance of the subsystems. In recent years, we formulated two system structuring techniques which could be used as fundamental tools for enhancing the subsystem autonomy: (1...

The promise of the grid is that it will enable public access and sharing of immense amounts of computational and data resources among a large number of individuals and institutions. However, the current grid solutions make several limiting assumptions that curtail their widespread adoption in the emerging decentralized, resource constrained, embedded, autonomic, and mobile (DREAM) environments:...

This paper addresses the challenge of multi-policy optimization in decentralized autonomic systems. We evaluate several multi-policy reinforcement learning-based optimization techniques in an urban traffic control simulation, a canonical example of a decentralized autonomic system. Our results indicate that W-learning, which learns separately for each policy and then selects between nominated a...

Multi-agent systems are autonomous decentralized platform software on which application programs such as business transactions, network provisioning and manufacturing control are deployed. In order for the applications to be truly autonomous and decentralized, however, heterogeneous multi-agent systems themselves must communicate and interoperate with each other. To solve the problem, we take a...

In this paper, a communication complexity view on the problem of decentralized controllability is presented, which uses ideas from information theory and distributed computation. To this end, we present a new approach to revisit a result on the characterization of the necessary and sufficient conditions for the existence of decentralized controllers for stability of linear systems under any cla...

This paper presents computer experiments concerning the decentralized pianola, a hypothetical mechanical music instrument, whose large-scale musical behavior is the result of local physical interactions between simple elements. Traditional mechanical music instruments like the pianola and the music box rely for their operation on the separation between a sequential memory unit and an execution ...