Andrographis paniculata has been studied for their potential protective action on benign prostate hypertrophy (BPH). This polyphenol reported to repair the antioxidant defense mechanisms in prostate, reduce inflammation, and inhibit IGF-I IGF-II. its (BPH) ability inflammation prostate. study aimed explore various scientific evidence related exploration of management These three studies consist...

Background: Researches on attachment theory shows that attachment styles influence marital adjustment. However, some psychological factors moderate this correlation. The present study was aimed to examine the moderating role of defense mechanisms in the association between attachment styles and levels of marital adjustment. Methods: This descriptive-correlational study collected data from a co...

BACKGROUND CD133-positive cells in hepatocellular carcinoma (HCC) exhibit cancer stem cell (CSC)-like properties as well as resistance to chemotherapeutic agents and ionizing radiation; however, their function remains unknown. In this paper, we identified a hitherto unknown mechanism to overcome CD133-induced resistance to anticancer therapy. METHODS We applied an alternative approach to enri...

Despite Coxiella burnetii being an obligate intracellular bacterial pathogen, our recent study demonstrated that B cells play a critical role in vaccine-induced immunity to C. burnetii infection by producing protective antibodies. However, the role of B cells in host defense against primary C. burnetii infection remains unclear. In this study, we investigated whether B cells play an important r...

Legumes form endosymbiotic interaction with host compatible rhizobia, resulting in the development of nitrogen-fixing root nodules. Within symbiotic nodules, rhizobia are intracellularly accommodated in plant-derived membrane compartments, termed symbiosomes. In mature nodule, the massively colonized cells tolerate the existence of rhizobia without manifestation of visible defense responses, in...

The aim of our study was to develop a method for selection of subpopulations of insulin producing RINm cells with higher resistance to beta cell toxins. Cells, resistant to streptozotocin (RINmS) and alloxan (RINmA), were obtained by repeated exposure of parental RINm cells to these two toxins, while the defense capacity was estimated by the MTT colorimetric method, and [3H]-thymidine incorpora...

Inflammation, a self-defensive reaction against various pathogenic stimuli, may become harmful self-damaging process. Increasing evidence has linked chronic inflammation to a number of neurodegenerative disorders including alzheimer's disease (AD), parkinson's disease (PD), and multiple sclerosis (MS). In the central nervous system, microglia, the resident innate immune cells play major role in...

One of the major complications in cancer chemotherapy is the development of resistance, and cisplatin, as one of the important medicines in treatment regimens of different cancers is not excluded. One of the most described cellular defense mechanisms involved in resistance is glutathione (GSH) and in this study, the effects of cisplatin on the total intracellular GSH level (GSHi) in some sensit...

after 11 september attack, anticipatory self defense has obtained specific situation in the doctrine ,of western states. these countries with financial and military power are seeking to justify this doctrine. this type of defense is contrary to article 51 of the charter of united nations that expresses the concept of self defense. in this paper, the authors are going to verify and show that thi...

one of the major complications in cancer chemotherapy is the development of resistance, and cisplatin, as one of the important medicines in treatment regimens of different cancers is not excluded. one of the most described cellular defense mechanisms involved in resistance is glutathione (gsh) and in this study, the effects of cisplatin on the total intracellular gsh level (gshi) in some sensit...