Background: Osteoarthritis is a degenerative joint disease that affects synovial joints and causes joint damage due to stresses caused by an abnormality in any of the synovial joint tissues, including articular cartilage, subchondral bone, ligaments, menisci, periarticular muscles, peripheral nerves, and synovium. Objectives: To compare the effect of Sensory Motor Training versus Impairment Ba...

Cheilectomy is the surgical resection of 20% to 30% of the dorsal metatarsal head and proximal phalanx. The present retrospective study evaluated the long-term efficacy of aggressive cheilectomy to address degenerative joint disease of the first metatarsophalangeal joint. To our knowledge, this is the second longest duration study to date to evaluate the long-term efficacy of the cheilectomy pr...

Joint diseases are widespread throughout the world. Up to 55% of structure articular pathology is due osteoarthritis (deforming arthrosis) [8]. Many foreign authors define this pathological process as [9, 36]. According most researchers, (OA) a polyetiological disease joints, characterized by impaired function, pain, deformity, and degenerative-destructive changes in tissue components [15]. In ...

Osteoarthritis (OA) is a degenerative joint disease with a high prevalence among older people. To date, the pathogenesis of the disease and the link between muscle function and OA is not entirely understood. As there is no known cure for OA, current research focuses on prevention and symptomatic treatment of the disorder. Recent research has indicated that muscle weakness precedes the onset of ...

Knee osteoarthritis is a very common degenerative disease. It affects the articular cartilage and subchondral bone and leads to its destruction. According to Osteoarthritis Research Society International (OARSI), the goal of treatment in osteoarthritis is to reduce joint stiffness and pain, improve function and mobility and stop the progression of joint destruction [1]. The chronic nature of th...

Osteoarthritis (OA) is a chronic degenerative joint disease and a major health problem in the elderly population. No disease-modifying osteoarthritis drug (DMOAD) has been made available for clinical use. Here we present a disease-modifying strategy for OA, focusing on messenger RNA (mRNA) delivery of a therapeutic transcription factor using polyethylene glycol (PEG)-polyamino acid block copoly...

Osteoarthritis is the most prevalent chronic degenerative joint disease involving articular cartilage and is a frequent cause of chronic joint pain, loss of function, and disability [1]. In men ages more than 50 years, osteoarthritis represents the second leading cause of work disability. Its incidence has doubled in women and tripled in men over the last 20 years [2]. The prevalence and incide...