نتایج جستجو برای: delayed expression

تعداد نتایج: 964022  

Journal: :Learning & memory 2013
Reto Bisaz Pere Boadas-Vaello David Genoux Carmen Sandi

Most of the mechanisms involved in neural plasticity support cognition, and aging has a considerable effect on some of these processes. The neural cell adhesion molecule (NCAM) of the immunoglobulin superfamily plays a pivotal role in structural and functional plasticity and is required to modulate cognitive and emotional behaviors. However, whether aging is associated with NCAM alterations tha...

2011
Santa J Ono Keith Lane

BACKGROUND Antihistamines constitute the first line of therapy for allergic conjunctivitis, and are safe and effective in relieving the signs and symptoms of ocular allergy. Despite this, they are less effective than some other drugs in relieving delayed symptoms of allergic conjunctivitis. Recent evidence suggests that changes in the conjunctival epithelium may underlie aspects of delayed reac...

2005
Ying Hu S. V. Penelope Jones Wolfgang H. Dillmann

Hyperthyroidism has been associated with atrial fibrillation (AF), however, hyperthyroidism induced ion channel changes which may predispose to AF have not been fully elucidated. To understand the electrophysiological changes occurring in left and right atrium with hyperthyroidism, the patch-clamp technique was utilized to compare action potential duration (APD) and whole cell currents in myocy...

Journal: :Biology of reproduction 2003
Jocelynn L Cook Maria C Shallow Dean B Zaragoza Kimberley I Anderson David M Olson

We explored a potential mechanism linking placental prostaglandins (PGs) with a fall in plasma progesterone and increased expression of uterine activation proteins in the mouse. PG endoperoxide H synthase 2 (PGHS-2) mRNA expression increased in placenta in late gestation in association with an 8-fold increase in PGF(2alpha) concentration, reaching a peak on Gestational Day (GD) 18. This peak co...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2010
Purna C Kashyap Kyoung Moo Choi Nirjhar Dutta David R Linden Joseph H Szurszewski Simon J Gibbons Gianrico Farrugia

Diabetic gastroparesis is associated with increased oxidative stress attributable to loss of upregulation of heme oxygenase-1 (HO1), with resultant damage to interstitial cells of Cajal and delayed gastric emptying. These changes can be reversed by induction of HO1. HO1 catalyzes the breakdown of heme into iron, biliverdin and, carbon monoxide (CO). The aim of this study was to determine whethe...

Journal: :Molecular endocrinology 2001
P E MacDonald X F Ha J Wang S R Smukler A M Sun H Y Gaisano A M Salapatek P H Backx M B Wheeler

In pancreatic beta-cells, voltage-dependent K(+) (Kv) channels are potential mediators of repolarization, closure of Ca(2+) channels, and limitation of insulin secretion. The specific Kv channels expressed in beta-cells and their contribution to the delayed rectifier current and regulation of insulin secretion in these cells are unclear. High-level protein expression and mRNA transcripts for Kv...

Journal: :American journal of physiology. Heart and circulatory physiology 2005
Ying Hu S V Penelope Jones Wolfgang H Dillmann

Hyperthyroidism has been associated with atrial fibrillation (AF); however, hyperthyroidism-induced ion channel changes that may predispose to AF have not been fully elucidated. To understand the electrophysiological changes that occur in left and right atria with hyperthyroidism, the patch-clamp technique was used to compare action potential duration (APD) and whole cell currents in myocytes f...

2012
Merja Korkalainen Katriina Huumonen Jonne Naarala Matti Viluksela Jukka Juutilainen

Ionizing radiation and certain other exposures have been shown to induce genomic instability (GI), i.e., delayed genetic damage observed many cell generations later in the progeny of the exposed cells. The aim of this study was to investigate induction of GI by a nongenotoxic carcinogen, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Mouse embryonic fibroblasts (C3H10T1/2) were exposed to 1, 10 or...

2009
Chushin Koh Fang-Xiang Wu Gopalan Selvaraj Anthony J. Kusalik

Computational gene regulation models provide a means for scientists to draw biological inferences from time-course gene expression data. Based on the state-space approach, we developed a new modeling tool for inferring gene regulatory networks, called time-delayed Gene Regulatory Networks (tdGRNs). tdGRN takes time-delayed regulatory relationships into consideration when developing the model. I...

Journal: :Communications in Mathematical Physics 2021

We study the stochastic colored six vertex (SC6V) model and its fusion. Our main result is an integral expression for natural observables of this model—joint q-moments height functions. This generalises a recent Borodin–Wheeler. The key technical ingredient new relation functions SC6V in neighboring points. independent interest; we refer to it as local relation. As applications, give proof cert...

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