At present time pharmaceutical research and development showing its interest on drug delivery. Which enhances therapeutic action while minimizing side effect. Use of multi-particulate is the gift of that research which achieve delayed or controlled release with low risk of dose dumping, flexibility of blending to attain different release pattern as well as reproducible and short gastric residen...

The feasibility of transdermal iontophoretic transport of 4 novel ester prodrugs of 5-OH-DPAT (glycine-, proline-, valine- and beta-alanine-5-OH-DPAT) was investigated in vitro and in vivo. Based on the chemical stability of the prodrugs, the best candidates were selected for in vitro transport studies across human skin. The pharmacokinetics and pharmacodynamic effects of the prodrug with highe...