Small guanosine triphosphatases of the Rab family regulate intracellular vesicular trafficking. Rab2 is highly expressed in the nervous system, yet its function in neurons is unknown. In Caenorhabditis elegans, unc-108/rab-2 mutants have been isolated based on their locomotory defects. We show that the locomotion defects of rab-2 mutants are not caused by defects in synaptic vesicle release but...

Morley’s skew plate and Razzaque’s are two standard benchmarkproblems used for the performance evaluation of finite elements. The referencesolutions these problems given thin case only, variousplate elements do not converge to solutions exactly. Accurate numericalsolutions proposed in this paper, which basedon element analysis on very dense meshes thick cases.

The antennal lobe of the brain of Manduca sexta comprises a central area of coarse neuropil surrounded by dense, spheroidal glomeruli, where all synaptic interactions between antennal-nerve axons and the second-order neurons of the lobe occur. Neuronal interactions in the glomeruli are complex, involving several types of neuritic profiles and mediated by synapses with a one-to-many ratio of pre...

There is a growing interest in on-line algorithms for analyzing and querying data streams, that examine each stream element only once and have at their disposal, only a limited amount of memory. Providing (perhaps approximate) answers to aggregate queries over such streams is a crucial requirement for many application environments; examples include large IP network installations where performan...

We present a hybrid atomistic–continuum computational framework for the treatment of dense fluid problems with emphasis on the coupling of molecular dynamics with continuum (finite element/spectral) methods for problems involving multi-fluid dynamics in the presence of multi-fluid interfaces. The technique is an extension of the single-fluid framework already presented by the author. The well-k...

Let R be an expansion of a dense linear order (R,<) without endpoints having the intermediate value property, that is, for all a, b ∈ R, every continuous (parametrically) definable function f : [a, b] → R takes on all values in R between f(a) and f(b). Every expansion of the real line (R, <), as well as every o-minimal expansion of (R,<), has the intermediate value property. Conversely, some ni...

Marsupial sex chromosomes break the rule that recombination during first meiotic prophase is necessary to ensure reductional segregation during first meiotic division. It is widely accepted that in marsupials X and Y chromosomes do not share homologous regions, and during male first meiotic prophase the synaptonemal complex is absent between them. Although these sex chromosomes do not recombine...

Densely-packed, all-digital aperture arrays form a key area of technology development required for the Square Kilometre Array (SKA) radio telescope. The design of real-time signal processing systems for digital aperture arrays is currently a central challenge in pathfinder projects worldwide. We describe an hierarchical, frequency-domain beamforming architecture for synthesising a sky beam from...

Two computational strategies have been proposed for motion analysis in the human visual system. Energy-based schemes involve detection of spatiotemporal Fourier energy in the frequency components comprising a moving pattern. Edge-based schemes track shifts in the position of local edges in the pattern over time. This paper describes a stimulus manipulation, spatial phase randomisation, that act...

In this paper, we develop a low-order three-dimensional finite-element solver for fast multiple-case crust deformation computation on GPU-based systems. Based on a highperformance solver designed for massively parallel CPU-based systems, we modify the algorithm to reduce random data access, and then insert OpenACC directives. By developing algorithm appropriate for each computer architecture, w...