The response of an F-actin network at the air-buffer interface to nonlinear compression is studied. We observe two distinct classes of behavior: a mechanically induced structural reorganization of the monolayer and a subsequent reversible, nonlinear mechanical response. Measurements of pressure area isotherms, bulk modulus, and the epifluorescence microscopy of tracer beads provide evidence tha...

The availability of specific imaging probes is the nuclear fuel for molecular imaging by positron emission tomography and single-photon emission computed tomography. These two radiotracer-based imaging modalities represent the prototype methods for noninvasive depiction and quantification of biochemical processes, allowing a functional characterization of tumor biology. Avariety of powerful rad...

Fig. 1. F-FDG PET/CT images revealing marginated abdomino-pelvic soft tissue density mass displacing the bowel loops and infiltration of the mesentry with heterogeneously increased tracer uptake (A and F; arrow). Additionally, there was evidence of metabolically active metastatic disease involving bilateral lungs (B), multiple skeletal muscles (C), multiple subcutaneous nodules (C), liver (D; a...

The Lorentz model constitutes a reference model for transport in disordered materials. Here a tracer meanders through an array of frozen obstacles which in the simplest variant are assumed to be distributed independently. As the density of scatterers increases, the regions of excluded volume start to overlap until eventually long-range transport ceases to exist entirely. This localization trans...