Dental pulp is a highly specialized mesenchymal tissue that has a limited regeneration capacity due to anatomical arrangement and post-mitotic nature of odontoblastic cells. Entire pulp amputation followed by pulp space disinfection and filling with an artificial material cause loss of a significant amount of dentin leaving as life-lasting sequelae a non-vital and weakened tooth. However, regen...

OBJECTIVES Few studies investigated the isolation of stem cells from pathologically injured dental tissues. The aim of this study was to assess the possibility of isolation of stem cells from pulp polyps (chronic hyperplastic pulpitis), a pathological tissue produced in an inflammatory proliferative response within a tooth. STUDY DESIGN Pulp polyp tissues were enzymatically digested and the h...

Patients with Vitamin D-resistant rickets have abnormal tooth morphology such as thin globular dentin and enlarged pulp horns that extend into the dentino-enamel junction. Invasion of the pulp by microorganisms and toxins is inevitable. The increased fibrotic content of the pulp, together with a reduced number of odontoblasts, decreases the response to pulp infection. The most important oral fi...

Interest in the use of engineered nanomaterials (ENMs) as either nanomedicines or dental materials/devices in clinical dentistry is growing. This review aims to detail the ultrafine structure, chemical composition, and reactivity of dental tissues in the context of interactions with ENMs, including the saliva, pellicle layer, and oral biofilm; then describes the applications of ENMs in dentistr...

We provide a detailed characteristic of stem cells isolated and expanded from the human dental pulp. Dental pulp stem cells express mesenchymal cell markers STRO-1, vimentin, CD29, CD44, CD73, CD90, CD166, and stem cell markers Sox2, nestin, and nucleostemin. They are multipotent as shown by their osteogenic and chondrogenic potential. We measured relative telomere length in 11 dental pulp stem...

Dens invaginatus is a developmental anomaly that results in an enamel-lined cavity intruding into the crown or root before the mineralization phase. It typically affects permanent maxillary lateral incisors, central incisors, and premolars. This paper describes the root canal treatment of Oehlers' type II dens invaginatus in maxillary left lateral incisors. A 16-year-old boy presented to the Fa...

background: dental pulp stem cells can be used in regenerative endodontic therapy. the aim of this study was to introduce an efficient method for dental pulp stem cells isolation. materials and methods: in this in-vitro study, 60 extracted human third molars were split and pulp tissue was extracted. dental pulp stem cells were isolated by the following three different methods: (1) digestion of ...

Non surgical root canal treatment is carried out to salvage the teeth in oral cavity. Although the success rate is found to be ranging from 81-95%, for variety of reasons failure of root canal is still seen in day to day practice. This is a cross sectional study done in Nepali population to evaluate the causes for such failures. It was found that inadequate obturation (45%) was the major cause ...

Two new Parasavaljevia species are described, one from Puerto Madryn, and one from El Límite beach, San Jorge Gulf, Chubut Province, Argentina. The two species are characterised by a combination of characters. Parasavaljevia uncinoa n. sp. is characterised by having a long rectangular cirrus, positioned at the level of the inner labial setae, rectangular mandibles with prominent lateral hooks b...

INTRODUCTION A critical step in biomaterial selection effort is the determination of material as well as the biological properties of the target tissue. Previously, the selection of biomaterials and carriers for dental pulp regeneration has been solely based on empirical experience. METHODS In this study, first, the linear viscoelastic material functions and compressive properties of miniatur...