Phosphonoformate was found to be an inhibitor of the deoxyribonucleic acid polymerase induced by the herpesvirus of turkeys. The apparent inhibition constants were 1 to 3 muM. Phosphonoformate was also able to block the replication in cell culture of Marek's disease herpesvirus, the herpesvirus of turkeys, and herpes simplex virus. It was as effective as phosphonoacetate. Phosphonoformate was n...

Genetic relationships among two strains of Treponema pallidum (Nichols and KKJ) and a strain of T. pertenue were determined by measuring the degree of deoxyribonucleic acid sequence homology. The results in indicated that these three virulent, noncultivable treponemes were genetically indistinguishable. Like T. pallidum (Nichols), T. pertenue (Gauthier) had no detectable deoxyribonucleic acid s...

Regulation of argA operon expression in Escherichia coli K-12 was studied in a cell-free, deoxyribonucleic acid-dependent, enzyme-synthesizing system. lambdaAZ-7 deoxyribonucleic acid, which carries a fusion of the lacZ structural gene to the argA operon so that beta-galactosidase synthesis is under argA regulation, was used as the template. To eliminate extraneous readthrough from lambda promo...

The observation of Boman and Kaletta (I, 2) that venom phosphodiesterase is capable of hydrolyzing the so called native thymus deoxyribonucleic acid has been confirmed in several laboratories (3-5). Boman (6) noticed that under appropriate conditions the reaction may be carried almost to completion. All these experiments were performed with comparatively crude preparations of phosphodiesterase....

The effect of colicins on deoxyribonucleic acid and protein synthesis, and also their effect on the ability of T4 phage to replicate in Escherichia coli K-12, were studied. Colicins of type K inhibited deoxyribonucleic acid synthesis, protein synthesis, and phage growth. Among colicins of type E, there was an absolute correlation between mode of action and subdivision into types E(1), E(2), and...

INTRODUCTION .......................................................... 409 PURIFUICATION OF PLASMID DEOXYRIBONUCLEIC ACID FROM STREPTCOCCI ......................................................... 412 CONJUGATION AND PLASMID TRANSFER ......... ........................ 413 SEX PHEROMONES IN STREPTOCOCCUS FAECALIS ....... ................ 415 RESISTANCE TRANSFER IN THE ABSENCE OF PLASMID DEOXYRI...