background: diabetes mellitus is an alarming life style disease in the modern world. exploitation of the anti-diabetic drugs for the amelioration of diabetes and associated life style diseases has become an imperative concern. in this milieu, this study was designed to explore the plausible effects of metformin intervention on hepatic and renal functions in a rat model of alcoholic liver diseas...

objective(s): abnormal lung cell death including autophagy and apoptosis is the central feature in acute lung injury (ali). to identify the cellular mechanisms and the chronology by which different types of lung cell death are activated during lipopolysaccharide (lps)-induced ali, we decided to evaluate autophagy (by lc3-ii and autophagosome) and apoptosis (by caspase-3) at different time point...

Jefferson C. Frisbee, Adam G. Goodwill, Stephanie J. Frisbee, Joshua T. Butcher, Robert W. Brock, I. Mark Olfert, Evan R. DeVallance, and Paul D. Chantler Department of Physiology and Pharmacology, West Virginia University Health Sciences Center, Morgantown, West Virginia; Department of Health Policy, Management and Leadership, West Virginia University Health Sciences Center, Morgantown, West V...

Immune serum was prepared against phosphate-dependent glutaminase purified from rat kidney and was used to investigate the cause of increased renal glutaminase activity in acidotic rats. Crude kidney homogenates from acidotic rats exhibited a fourfold greater specific activity for phosphate-dependent glutaminase. The glutaminase was solubilized initially by lyophilization of borate treated mito...

background: chronic administration of morphine cause physical dependence but the exact mechanism of this phenomenon remains unclear. the aim of this study is the assessment of systemic and intracerebroventricular (icv) administration of ramelteon (a melatonin receptor agonist) on morphine physical dependence. methods: 88 adult male rats were divided into 2 major groups, namely “systematic” and ...

in this study, the possible involvement of l-type voltage-operated calcium channels in the vasorelaxant effect of the flavonoid quercetin was investigated, using the isolated aortic rings from normal male rats. addition of quercetin (0.1 µm-1 mm) caused a significant dose-dependent relaxation of noradrenaline (na)- and kcl-preconstricted rings and nifedipine attenuated this response, especially...

The study was designed to evaluate the anti-diabetic effect of aqueous extract of Bauhinia tomentosa L. leaf on alloxan induced Wistar albino rats. Diabetes was induced in albino rat models with alloxan monohydrate (150mg/kg body weight). Aqueous leaf extract of Bauhinia tomentosa at the dose of 300 mg/kg was orally administered once a day for 30 days to the diabetic animals. In this study, gly...

BACKGROUND An overlapping distribution of α2-adrenergic receptors with cannabinoid receptors has been reported in certain brain structures such as the dorsal hippocampus. Thus, functional interactions between cannabinoid and α2-adrenergic systems in cognitive control seem possible. In the present study, we examine the possible role of α2-adrenergic receptors of the dorsal hippocampus on WIN55,2...

growth of the prostate gland, also development of benign prostatic hyperplasia (BPH) is an androgen-dependent functions. Testosterone plays a major role in the prostate gland. Rat prostate gland is one of the most widely used models of animals in investigation. The rat prostate gland consisted of five lobes; the ventral, anterior, dorsal, lateral type 1 and latteral type 2. The goal of present ...

objective: transplantation of mesenchymal stem cells (mscs) can promote functional recovery of the brain after hypoxic-ischemic brain damage (hibd). however, the mechanism regulating msc migration to a hypoxic-ischemic lesion is poorly understood. interaction between stromal cell-derived factor-1α (sdf-1α) and its cognate receptor cxc chemokine receptor 4 (cxcr4) is crucial for homing and migra...