introduction: barrel cortex of rats is a part of somatosensory cortex, which receives information from facial whiskers. vibrisectomy by sensory deprivation leads to some changes in the barrel cortex, which have been known as experience dependent plasticity. on the other hand, norepinephrine (ne) and locus coeruleus, which is the main source of ne, influenced response properties of cortical barr...

This study aimed to investigate the dose-dependent and time-dependent effect of magnetic iron oxide nanoparticles (MIONPs) on reproduction in male rats. Following their synthesis, physicochemical properties MIONPs were determined. Sixty-four adult rats, aged 90 days randomly assigned control (C), orally administered with distilled water, three treated groups, 1, 5, 10 mg/kg/day solution (TL, TM...

In humans, hypercholesterolemia and hypertriglyceridemia induce endothelial dysfunction and therefore lead to atherosclerosis. In contrast, rats are resistant to atherosclerosis. Here we analyze whether rats respond to hypercholesterolemia and hypertriglyceridemia by developing of endothelial dysfunction. To induce hypercholesterolemiaWistar-Kyoto (WKY) and spontaneous hypertensive (SHR) rats w...

To study the mechanisms of vascular dysfunction in diabetes mellitus, we examined the responses of the aorta to adrenomedullin (AM) and ANG II in obese Zucker (OZ), lean Zucker (LZ), and OZ rats administered fluvastatin (OZ + Flu). AM-induced endothelium-dependent vasorelaxation was impaired in OZ rats compared with LZ rats, and fluvastatin restored AM-induced, endothelium-dependent vasorelaxat...

background: traditional medicines with anti-diabetic effects are considered suitable supplements to treat diabetes. among medicinal herbs, stevia rebaudiana bertoni is famous for its sweet taste and beneficial effect in regulation of glucose. however, little is known about the exact mechanism of stevia in pancreatic tissue. therefore, this study investigated the possible effects of stevia on pa...

Voluntary exercise has proved to be an effective therapeutic tool improve cardiac function in aged rats with clearly visible sex differences. Long-term is associated decreased Ogn and Comt expression enhanced presence of Pcp4 Esm1 genes. Sex-dependent changes were also observed the cardiovascular key proteins. Fundamental alterations gene protein may contribute improvement performance.

objective(s) in recent years concerns have been raised regarding the incidence of male reproductive disorders from exposure to endocrine disruptors. so, chronic effects of di(2-ethylhexyl)phthalate were studied on histological and stereological structure of testis in adult wistar rats. materials and methods thirty two adult wistar rats were randomly divided in four equal experiment groups; oil ...

Drug abuse is a public health and social problem. A number of studies have reported that drug addiction is associated with microRNAs (miRNAs). By comparing the expression of miRNAs in the serum exosomes of methamphetamine-dependent and ketamine-dependent rats, the aim of the present study was to provide insights into the miRNA-mediated associations between the two groups. Published results on c...

This study was carried out to evaluate the protective effects of polyherbal extract against gentamicin induced renal injury in rats. 36 male Wistar rats were divided into six groups. Gentamicin administered (100 mg/kg, intraperitoneally for 10 d) all groups except normal control group. Polyherbal three (gentamicin+polyherbal 100 gentamicin+polyherbal 200 mg/kg and 300 mg/kg) at 100, body weight...

Background: Apelin has recently been identified as an analgesic agent and a novel neuropeptide. On the other hand, it has been shown that exercise can lead to reduced pain in morphine-dependent patients. Objectives: Therefore, the aim of this study was to evaluate apelin and pain threshold changes in healthy and morphine-dependent rats in response to two exercise paradigms. Materials and Method...