Abstract In this paper, we study the recently introduced time-constrained maximal covering routing problem. problem, are given a central depot, set of facilities, and customers. Each customer is associated with subset facilities which can cover it. A feasible solution consists k Hamiltonian cycles on subsets depot. cycle must contain depot respect distance limit. The goal to maximize number cus...

On the 2nd of July, 1881, as President Garfield was entering the depot at Washington, leaning on the arm of Mr. Blaine, Secretary of State, Guiteau, who had been lounging about the depot waiting for his victim, got behind him, and fired two bullets into the President's back ; the wound proved mortal, the President dying on September 19th, 1881. From the day on which Gruiteau shot the President ...

CLINICAL CASES The pinguecula is a degenerative lesion which is usually asymptomatic, except when it is associated with an inflammatory reaction. We present 2 clinical cases of patients that had symptomatic pinguecula, in which intra-lesional betamethasone in depot form was used as treatment, obtaining a significant clinical improvement. DISCUSSION The administration of intra-lesional betamet...

Leuprolide acetate is a long-acting GnRH analog. A single injection of LUPRON DEPOT–3 Month 11.25 mg will result in an initial stimulation followed by a prolonged suppression of pituitary gonadotropins. Repeated dosing at quarterly (LUPRON DEPOT–3 Month 11.25 mg) intervals results in decreased secretion of gonadal steroids; consequently, tissues and functions that depend on gonadal steroids for...

Several challenges are associated with current vaccine strategies, including repeated immunizations, poor patient compliance, and limited approved routes for delivery, which may hinder induction of protective immunity. Thus, there is a need for new vaccine adjuvants capable of multi-route administration and prolonged antigen release at the site of administration by providing a depot within tiss...

One hundred and twenty seven outpatient schizophrenics treated with fluphenazine decanoate (Modecate) depot therapy for a minimal period of 24 months were selected from all the psychiatric outpatient clinics in Singapore. Using a mirror image analysis in which patients act as their own controls, 105 patients showed a significant reduction of relapses requiring admissions from 139 before the ins...

Derived from the well-known Traveling Salesman problem (TSP), the multiple-Traveling Salesman problem (multiple-TSP) with single depot is a straightforward generalization: several salesmen located in a given city (the depot) need to visit a set of interconnected cities, such that each city is visited exactly once (by a single salesman) while the total cost of their tours is minimized. Designed ...