نتایج جستجو برای: descending inhibitory noceptive system
تعداد نتایج: 2360934 فیلتر نتایج به سال:
Introduction: Nucleus cuneiformis (NCF), as part of descending pain inhibitory system, cooperates with periaqueductal gray (PAG) and rostral ventromedial medulla (RVM) in supraspinal modulation of pain. Cannabinoids have analgesic effects in the PAG, RVM and NCF. The transient receptor potential vanilloid type 1(TRPV1) can be activated by anandamide and WIN55,212-2 as a cannabinoid receptor ago...
Background Endogenous pain inhibitory mechanisms are known to reduce intensity, but whether they influence the size and distribution of referral is unclear. This study aimed determine if referred reduced by applying a remote, conditioning painful stimulus. Methods Twenty-four healthy men participated in this randomized, crossover with control session. Referred was induced from infraspinatus mus...
Under intact and spinalized conditions, we compared the responses of deep spinal dorsal horn (DH) nociceptive-specific (NS) and wide-dynamic range (WDR) neurons to subcutaneous bee venom (BV, 0.2 mg/50 microl)-induced persistent nociception. In contrast to the monophasic, long-lasting (34-81 min) WDR neuron responses in both intact and spinalized conditions, BV in NS neurons elicited short-term...
Spinocerebellar tract neurons are inhibited by various sources of input via pathways activated by descending tracts as well as peripheral afferents. Inhibition may be used to modulate transmission of excitatory information forwarded to the cerebellum. However it may also provide information on the degree of inhibition of motoneurons and on the operation of inhibitory premotor neurons. Our aim w...
The electrosensory lateral line lobe (ELL) of weakly electric fish is the only nucleus that receives direct input from peripheral electroreceptor afferents. This review summarises the neurotransmitters, receptors and second messengers identified in the intrinsic circuitry of the ELL and the extrinsic descending direct and indirect feedback pathways, as revealed by recent in vitro and in vivo st...
Pain thresholds are, in part, set as a function of emotional and internal states by descending modulation of nociceptive transmission in the spinal cord. Neurons of the rostral ventromedial medulla (RVM) are thought to critically contribute to this process; however, the neural circuits and synaptic mechanisms by which distinct populations of RVM neurons facilitate or diminish pain remain elusiv...
1. Neuronal mechanisms underlying the directional sensitivity of the crayfish equilibrium system were studied in the brain by intracellular recording combined with mechanical statocyst hair deflection. 2. Five primary afferents were successfully characterized. Three of them showed a decrease in response to inward hair deflection. The remaining two showed the opposite directional response. 3. Di...
20 Injury of descending motor tracts remodels cortical circuitry and leads to enhanced 21 neuronal excitability, thus influencing recovery following injury. The neuron-specific 22 contributions remain unclear due to the complex cellular composition and connectivity of 23 the CNS. We developed a microfluidics-based in vitro model system to examine intrinsic 24 synaptic remodeling following axon ...
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