Genome-wide association scans for disease susceptibility genes of complex diseases require genotyping on a massive scale. A DNA pooling strategy for family-based association studies is described, which is robust to population stratification biases and to errors in pooling. It can achieve a statistical efficiency of 0.95 with approximately 1 of 8 or fewer genotyping efforts, and an efficiency of...

The suitability of random amplified polymorphic DNA-PCR for the detection of differences between Mycobacterium malmoense strains was evaluated. With two of the 32 tested primers seven fingerprint patterns which proved excellent in distinguishing intraspecies variations of M. malmoense were obtained. The combination of the results obtained with the two primers permitted a clear separation of the...

BACKGROUND AND PURPOSE Phenotype assessment of genetically modified rodents is an essential component of animal model development and their eventual use. Described here is a paradigm to consider as we collectively pursue phenotype assessment of the constantly increasing number of genetically modified rodent models, as well as those with spontaneously occurring mutations. METHODS Review of pas...

The present study introduces new Haplotype Sharing Transmission/Disequilibrium Tests (HS-TDTs) that allow for random genotyping errors. We evaluate the type I error rate and power of the new proposed tests under a variety of scenarios and perform a power comparison among the proposed tests, the HS-TDT and the single-marker TDT. The results indicate that the HS-TDT shows a significant increase i...

Using the terms of (Reiter and Dale, 2000), we consider that the Document Planner architecture is pipelined: first the content determination task does its work, and then the document structuring task takes the result and build a document plan. Following the work of (Roussarie, 2000), we adopt SDRT (Asher, 1993; Asher and Lascarides, 1998), which was designed first for text understanding, for th...

The nite size of a gravitational microlenses may have an eeect on the observed the am-pliication of a background point source. The mechanism is occlusion of one or more of the source images by the opaque bulk material of the lens travels by the source. To observe this phenomenon, the lensing geometry must be nely tuned so that the physical size of the lens is very near its Einstein radius. Whil...

The phonation threshold pressure (PTP) has been found to increase during vocal fatigue. In the present study we compare PTP and collision threshold pressure (CTP) before and after vocal loading in singer and non-singer voices. Seven subjects repeated the vowel sequence /a,e,i,o,u/ at an SPL of at least 80 dB @ 0.3 m for 20 min. Before and after this loading the subjects’ voices were recorded wh...

Introduction Uses Determination Technological Determination Social Determination Towards Non-Reductionist Research Footnotes Acknowledgments References About the Author

Policy Number: 670 BCBSA Reference Number: 2.04.111 NCD/LCD:  Local Coverage Determination (LCD): MolDX-CDD: Decipher Prostate Cancer Classifier Assay (L35868)  Local Coverage Determination (LCD): MolDX-CDD: ProlarisTM Prostate Cancer Genomic Assay (L35869)  Local Coverage Determination (LCD): MolDX: Prolaris Prostate Cancer Genomic Assay for Men with Favorable Intermediate Risk Disease (L37...