[18F]KF, considered as a reference standard for positron emission tomography of the skeletal system, was produced by the bombardment of enriched water ([18O]H2O>95%) with high energy protons in NRCAM cyclotron. After the extraction of fluoride from enriched water as KF, and passing it through microbial filter and fine adjustment of acidity and osmolality, it was converted into an injectab...

When fertilized and unfertilized eggs of Arbacia punctulata are suspended in heavy water, deuterium is incorporated into stable positions in the egg proteins. The rate of incorporation of the isotope is considerably greater in fertilized than in unfertilized eggs, and is accelerated at the time of formation of the blastula. The result of calculation of the maximum deuterium concentration which ...

Deuterium incorporation is crucial in organic synthesis and has wide applications the pharmaceutical industry. State-of-the-art H/D isotope exchange chemical defunctionalization for deuterium suffer from significant drawbacks, including expensive sources, low deuteration efficiency poor selectivity. In this perspective, we highlight an alternative pathway forming C-D bonds by electrocatalytic h...

Utilization of Photodisintegration reaction of Deuterium, 2H(?,n)1H, is a precise technique for determining the percentage of 2H in tritiated and natural water. The 23Na(n,?)24Na reaction is a suitable ?-source for producing the 2H(?,n)1H reaction. Tehran Research Reactor was used as a neutron source for producing 24Na isotopes. The BF3 detectors were used to detect the neutron emission of H2 c...

Deuterium labeling techniques are widely utilized as efficient tools to study the absorption, distribution, metabolism, and excretion (ADME) of pharmaceuticals. Moreover, deuterium-labeled drugs expected prolong half-life drug enhance efficacy drugs, close metabolic sites, decrease side effects. Thus, there is a rising demand for practical construction their intermediates under mild conditions....

We describe here a new technique for isolating nuclei from long-term label-retaining cells (LRCs), a subpopulation enriched with stem cells from colon, and for measuring their proliferation rates in vivo. A double-label approach was developed, combining the use of bromodeoxyuridine (BrdU) and (2)H(2)O. Male Fisher 344 rats were administered BrdU in drinking water continuously for 2-8 wk. BrdU w...