BACKGROUND Gefitinib and/or erlotinib-induced hepatotoxicity sometimes lead to treatment failure in EGFR mutation-positive patients with non-small cell lung cancer (NSCLC), even though the therapeutic effect is evident. CASES Here, we report three postoperative NSCLC patients with recurrences who experienced severe hepatotoxicity while receiving gefitinib and/or erlotinib treatment but could ...

Propylthiouracil (PTU) is often used to produce experimental hypothyroidism. In general, PTU generates hepatotoxicity, albeit with dissimilar incidence rates of hepatotoxicity. This study examined the hepatoprotective effects Saussurea lappa root ethanol extract on experimentally induced hepatotoxicity in female rats. For this study, 25 adult albino rats were placed into five equal groups: cont...

We investigated the effect of garlic oil (GO), alone or combined with low dose total body gamma (γ)-irradiation (LDR) against paracetamol (APAP)induced hepatotoxicity in rats. GO (100 mg/kg/day) was administered orally for 14 days before hepatotoxicity induction.Animals were irradiated 2 hours before hepatotoxicity induction by peroral APAP (1g/kg) administration, then animals were sacrificed 2...

Paracetamol (PCM) is widely used as analgesic and antipyretic drug, but at high dose it leads to undesirable side effects, such as hepatotoxicity. This study gives the information about hepatoprotective activity of abelmoschus moschatus seed extract against paracetamol and ethanol induced hepatotoxicity. Paracetamol induce hepatotoxicity was evaluated by an increase (P<0.05) in serum AST, ALT, ...

Herbals and dietary supplements (HDS) can cause hepatotoxicity. Regulation of HDS varies across the globe. In the United States, it is defined by a law that is now two decades old. More recent regulatory approaches in Europe still do not require testing for premarket safety. The true incidence of hepatotoxicity from HDS is unknown. The presentation is most often with a hepatocellular enzyme pat...

Hepatotoxicity refers to liver dysfunction associated with certain medical drugs and chemicals. Studies have shown that mesenchymal stem cells a positive effect on the improvement of diseases. The aim this study was investigate potential protective effects fetal kidney-induced Doxorubicin-induced hepatotoxicity in rats. Sprague dawley rats were divided into three groups as control, sham, treatm...

background: massularia acuminata has been claimed to be used in managing several ailments in folk medicine and in some instances substantiated with scientific data. this however has been without recourse to its safety. therefore, aqueous stem extract of m. acuminata was evaluated for its effects on some function indices of the liver of male rats. methods: sixty, male rats were grouped into 4 (a...

the pyrrolizidine alkaloids (pas) are a group of chemicals found in a variety of plant species throughout the world. these toxic alkaloids are distributed mainly in senecio (compositae), crotalaria (legominosae) and heliotropium (boraginaceae) species. plants containing these alkaloids cause significant mammalian morbidity and mortality, especially in humans. upon ingestion, metabolic activatio...

the ameliorative activity of aqueous extract of the flesh of dates (phoenix dactylifera l.) and ascorbic acid on thioacetamide-induced hepatotoxicity was studied in rats. sixty male rats were divided into six equal groups of 10. two groups were controls, one treated with thioacetamide and one with only distilled water. two groups received extract of flesh phoenix dactylifera and intraperitoneal...

in india, a number of medicinal plants and their formulations are used to cure hepatic disorders in traditional systems of medicine. no systemic study has been done on protective effect of cucumis trigonus roxb. (cucurbitaceae) to treat hepatic diseases. protective action of c. trigonus fruit extracts was evaluated in this study in animal model of hepatotoxicity, which was induced by carbon tet...