BACKGROUND The highly selective α2 -adrenoreceptor agonist, dexmedetomidine, exerts neuroprotective, analgesic, anti-inflammatory and sympatholytic properties that may be beneficial for perinatal asphyxia. The optimal safe dose for pre-clinical newborn neuroprotection studies is unknown. METHODS Following cerebral hypoxia-ischaemia, dexmedetomidine was administered to nine newborn piglets in ...

OBJECTIVE The aim of this study was to investigate the optimum dosage of dexmedetomidine for prevention of postanesthetic shivering. METHODS One-hundred thirty two ASA physical status I-II patients scheduled for elective laparoscopic total hysterectomy were enrolled in this randomised, placebo-controlled study. Patients were randomly allocated to receive dexmedetomidine in four groups: group ...

BACKGROUND Work suggests the amnesia from dexmedetomidine (an α2-adrenergic agonist) is caused by a failure of information to be encoded into long-term memory and that dexmedetomidine might differentially affect memory for emotionally arousing material. We investigated these issues in humans using event-related neuroimaging to reveal alterations in brain activity and subsequent memory effects a...

BACKGROUND the present study was designed to compare the efficacy, tolerability and safety of dexmedetomidine and fentanyl when combined with propofol during extracorporeal shock wave lithotripsy in children. METHODS fifty children aged 3-8 years, the American Society of Anesthesiologists status I and II, scheduled for elective extracorporeal shock wave lithotripsy were randomly allocated to ...

Editor’s key points † Dexmedetomidine may offer advantages over midazolam when used for sedation in Intensive Care Unit (ICU) patients. † The authors undertook a critical appraisal of randomized controlled trials which have addressed this issue. † So far the evidence of advantages of dexmedetomidine in ICU setting remains limited. † The authors recommend more research using robust methodology a...

CONTEXT Studies suggest that dexmedetomidine-an intravenous central-acting α2-adrenergic agonist that effectively reduces anxiety among critically ill patients-is being used in patients with severe alcohol withdrawal. However, evidence supporting its use is limited, and it is not approved for this indication. OBJECTIVE To assess the effect of dexmedetomidine on severe alcohol withdrawal sympt...

We report a series of successful awake fiberoptic intubations in patients with critical (unstable, difficult) airways using the alpha(2)-agonist, dexmedetomidine. Dexmedetomidine has several desirable pharmacologic properties, including sedation, anxiolysis, hypnosis, analgesia, amnesia, antisialagogue effects, and a unique respiratory-sparing effect. Dexmedetomidine appears to be a useful agen...

Corresponding author: Jaemin Lee, M.D., Department of Anesthesiology and Pain Medicine, Seoul St. Mary’s Hospital, Banpo-dong, 504, Seocho-gu, Seoul 137-701, Korea. Tel: 82-2-2258-6153, Fax: 82-2-537-1951, E-mail: [email protected] This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/...

Marhofer and colleagues Malenfant Rancourt and colleagues Site Ulnar nerve (volunteers) Posterior tibial nerve (volunteers) Medication 3 ml ropivacaine 0.75% 10 ml ropivacaine 0.5% Dose of adjuvant 20 mg dexmedetomidine 1 mg kg dexmedetomidine ( 50–70 mg) Results Sensory block 350(SD 54) min ropivacaine only(5.8 h) vs 555 (118) min ropivacaine+ dexmedetomidine (9.25 h) 972 (SD 120) min ropivaca...

Postoperative cognitive dysfunction (POCD) is a kind of serious neurologic complications and dexmedetomidine has a certain effect on POCD. However, functional mechanism of dexmedetomidine on POCD still remains unclear, so the research mainly studied the effect of dexmedetomidine on cognitive function and protein expression in hippocampus and prefrontal cortex cerebrospinal fluid after extracorp...