2-O-α-d-Glucopyranosyl-l-ascorbic acid (AA-2G) is one of the stable ascorbic acid (AA) derivatives known as provitamin C agents. We have previously synthesized two types of monoacylated derivatives of AA-2G, 6-O-acyl-2-O-α-d-glucopyranosyl-l-ascorbic acids having a straight-acyl chain of varying length from C₄ to C18 (6-sAcyl-AA-2G) and a branched-acyl chain of varying length from C₆ to C16 (6-...

In previous studies we found that a commercial cholesterol preparation obtained from the Wilson Laboratories had a high concentration of antirachitic provitamin. In the present studies we undertook to concentrate the provitamin fraction in cholesterol and to study its properties. 175 gm. of the commercial product, Cholesterol W, were dissolved in 1200 cc. of 10 per cent solution of sodium hydro...

Case Report A 50-year-old woman developed a pruritic rash on her hands and forearms, spreading to the trunkwhile sparing the upper arms, after applying an ointment (Totes Meer Pflegebalsam®) and a skin aerosol (Panthenol Spray®) to treat irritant hand eczema caused by intensive gardening. Patch tests with the original products and several test series of the German Contact Dermatitis Research Gr...

Background: Recurrent aphthous stomatitis (RAS) is a common condition, which is characterized by multiple recurrent small, round or ovoid, ulcers with circumscribed margins, erythematous haloes, and yellow or grey floors typically presenting in childhood or adolescence. The treatment of RAS is principally directed towards reducing pain and duration of each episode of ulceration. The aim of this...

Coenzyme Q10 (CoQ10) is a lipid-soluble molecule found naturally in many eukaryotic cells and is essential for electron transport chain and energy generation in mitochondria. D-Panthenyl triacetate (PTA) is an oil-soluble derivative of D-panthenol, which is essential for coenzyme A synthesis in the epithelium. Liposomal formulations that encapsulate both ingredients were prepared and optimized ...

Background: Vitamin A (VA) and zinc deficiencies are prevalent. Maize is a common staple, and milling affects nutrient and nutrient-modifier profiles.Objective: We investigated the interaction of maize milling methods (i.e., whole grain compared with refined) in male Mongolian gerbils aged 29-35 d with conventionally bred provitamin A-biofortified (orange) or white maize on VA and zinc status.M...

Introduction Wound is defined simply as the disruption of the cellular and anatomic continuity of a tissue (Bennet 1988). Wound may be produced by physical, chemical, thermal, microbial or immunological insult to the tissue. The process of wound healing consists of integrated cellular and biochemical events leading to reestablishment of structural and functional integrity with regain of strengt...

Infectious and allergic diseases of the upper airways are among the most common illnesses of all age groups. Numerous guidelines have been issued for the evidence-based treatment of these diseases. Therapy involves local or systemic application of well-characterized pharmacologically active medications such as glucocorticosteroids, antihistamines, leukotriene-receptor antagonists, alpha-adrener...

THE absorption spectrum of cod-liver oil possesses a quite special interest because of the fact that the oil contains three known important substances which are sensitive towards light, namely, vitamin A, ergosterol or provitamin D and vitamin D itself. A number of workers have studied the absorption spectrum of the medicinal oil, and Schlutz and his colleagues [1925, 1926] and Heilbron, Kamm a...