نتایج جستجو برای: dexrazoxane

تعداد نتایج: 227  

Journal: :The Journal of clinical investigation 2014
Yoshihiko Ichikawa Mohsen Ghanefar Marina Bayeva Rongxue Wu Arineh Khechaduri Sathyamangla V Naga Prasad R Kannan Mutharasan Tejaswitha Jairaj Naik Hossein Ardehali

Doxorubicin is an effective anticancer drug with known cardiotoxic side effects. It has been hypothesized that doxorubicin-dependent cardiotoxicity occurs through ROS production and possibly cellular iron accumulation. Here, we found that cardiotoxicity develops through the preferential accumulation of iron inside the mitochondria following doxorubicin treatment. In isolated cardiomyocytes, dox...

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