We investigated the relationship between protein and tryptophan intake and the adverse-effect-level of di(2-ethylhexyl)phthalate (DEHP). Growth retardation of young rats due to DEHP was strengthened by increasing protein level. The addition of tryptophan to the diet caused extreme increases in the nicotinamide formation, but no growth retardation was observed.

Phthalate diesters have been shown to be developmental and reproductive toxicants in animal studies. A recent epidemiologic study showed certain phthalates to be significantly associated with reduced anogenital distance in human male infants, the first evidence of subtle developmental effects in human male infants exposed prenatally to phthalates. We used two previously published methods to est...

BACKGROUND Phthalates are a group of environmental endocrine disruptors and have been ubiquitously applied in industrial field. Few studies had investigated how dietary intake was related with phthalate body burden in children. To determine the relationship between phthalate body burden and dietary intake among school age children in Shanghai, China. METHODS Four hundred and thirty schoolchil...

Phthalate esters have been used extensively as plasticizers of synthetic polymers. Recent studies have revealed that these esters induce atrophy of the testis, although its pathogenesis remains unknown. The present study describes the possible involvement of oxidative stress in the pathogenesis of atrophy of the rat testis induced by di(2-ethylhexyl)phthalate (DEHP). Biochemical and immunohisto...

Premature breast development (thelarche) is the growth of mammary tissue in girls younger than 8 years of age without other manifestations of puberty. Puerto Rico has the highest known incidence of premature thelarche ever reported. In the last two decades since this serious public health anomaly has been observed, no explanation for this phenomenon has been found. Some organic pollutants, incl...

A large number of industrial chemicals and environmental pollutants, including trichloroethylene (TCE), di(2-ethylhexyl)phthalate (DEHP), perfluorooctanoic acid (PFOA), and various phenoxyacetic acid herbicides, are nongenotoxic rodent hepatocarcinogens whose human health risk is uncertain. Rodent model studies have identified the receptor involved in the hepatotoxic and hepatocarcinogenic acti...

The adsorption of Bis (2-ethylhexyl) phthalate (DEHP) on the carbon adsorbents (Chezacarb S and Chezacarb SH) and polymer adsorbent on basis of polypropylene with polyethylene (Reo Fb) was studied. Efficiency of DEHP adsorption (concentration DEHP to 10 g.L, concentration of the adsorbents 1.7 g.L) was more then 99.9 %. By the sample from groundwater was efficiency more as 99.7 % in the case of...

Phthalates are multifunctional chemicals used in a variety of applications, including personal care products. The present study explored the relationship between patterns of personal care product use and urinary levels of several phthalate metabolites. Subjects include 406 men who participated in an ongoing semen quality study at the Massachusetts General Hospital Andrology Laboratory between J...

To study the toxic effects of phthalate esters on the aquatic creatures, carps were exposed to dibutyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP) of six different concentrations for 96 h-LC50 measurements. It shows that the 96 h-LC50 is 16.30 and 37.95 mg L(-1), thus the safe concentration (1/10LC(50)) is 1.63 mg L(-1). The activities of xanthine oxidase (XOD) and catalase (CAT) were ...