1 Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China 2The University of Hong Kong, Pokfulam, Hong Kong 3University of Pittsburg, Pittsburgh, PA 15261, USA 4Chinese Academy of Science, Shanghai 200031, China 5 Pennington Biomedical Research Center, Louisiana State University, Baton Roug...

A GENERAL review of the more important aspects of diabetes mellitus is desirable before proceeding to a consideration of the particular problem of the ocular complications. Diabetes mellitus, already a common disease, is likely to become more common in the future. It has been estimated that in the United States of America there are about 1 million diabetics and probably another million undiscov...

svm hlood pressure was 165/90 it had risen now to 205/105. Apart from the usual Was^t0mS diabetes, she complained of ankle swelling and shortness of breath. She in ^at anc* was therefore given a low calorie diet which caused her to lose 14 lb. jje^ei?ht; her urine became sugar-free, and her blood sugar fell to normal levels, tetr Urinary infection was due to Bacillus coli which was sensitive to...

Diabetic ketoacidosis (DKA), hyperglycemic hyperosmolar state (HHS), lactic acidosis (LA), and hypoglycemia are acute and potentially life-threatening complications of diabetes. DKA and severe hypoglycemia are more common in type 1 diabetes, while HHS without ketoacidosis is associated more frequently with type 2 diabetes. In the United States, the SEARCH for Diabetes in Youth study reported th...

There remains a critical need to better understand the underlying disease mechanisms responsible for diabetes complications in order to develop new and improved therapeutic strategies for these chronic conditions. These complications are broadly classified as microvascular, including neuropathy, nephropathy, and retinopathy, or macrovascular, including cardiovascular and peripheral vascular dis...

Diabetes may affect the musculoskeletal system in a variety of ways. The metabolic perturbations in diabetes (including glycosylation of proteins; microvascular abnormalities with damage to blood vessels and nerves; and collagen accumulation in skin and periarticular structures) result in changes in the connective tissue. Musculoskeletal complications are most commonly seen in patients with a l...

The acute metabolic complications of diabetes consist of diabetic ketoacidosis (DKA), hyperosmolar non-ketotic coma (HNC), lactic acidosis (LA), and hypoglycemia. DKA and HNC are related to insulin deficiency. Hypoglycemia results from the treatment of diabetes, either with oral agents or insulin. Although hypoglycemia may occur in conjunction with oral hypoglycemic therapy, it is more common i...