THE ANTIDIURETIC PROPERTIES OF CHLOROTHIAZIDE IN DIABETES INSIPIDUS DOGS. II. Possible Role of the Adrenal Gland

In spite of its rare incidence, the inherited renal tubular disorder nephrogenic diabetes insipidus (NDI) has in the past 10 years attracted the attention of a varied group of medical doctors and basic scientists. With the identification of the two genes involved in NDI, namely the vasopressin type-2 receptor (V2R) and the aquaporin-2 water channel (AQP2) genes, the identification of a large nu...

Hypernatremia will develop when a patient with nephrogenic diabetes insipidus cannot drink enough water to match her large obligatory urinary water loss. In preparation for monitoring labor and delivery in a woman with hereditary nephrogenic diabetes insipidus (NDI), our objective was to avoid dysnatremias and plan how to treat one should one occur. Specific concerns were raised regarding her a...

Diagnosis and treatment of Langerhans cell histiocytosis (LCH) in elderly patients are often difficult. We report here a 61-year-old female suffering from a refractory axillary ulcer for nearly a year, whose biopsy revealed LCH. It was also noted that the patient had other cutaneous papulovesicular eruptions of LCH as well as central diabetes insipidus. The patient was first successfully treate...

A patient with ectopic pinealoma first presented with apparent anorexia nervosa and hypernatraemic coma. A history of diabetes insipidus two months previously was not known on admission to hospital. The diabetes insipidus was unmasked by the administration of steroids. Neuroendocrinal and neuropathological aspects of the case are discussed with reference to the march of symptoms due to the grow...

We report a female infant with facial dysmorphism, ectrodactyly, holoprosencephaly, and associated hypernatremia. A 7-month-old female infant with cleft lip and palate, and ectrodactyly was admitted to our hospital with recurrent hypernatremic dehydration. Magnetic resonance imaging revealed holoprosencephaly. Plasma osmolality was increased whereas urinary osmolality was decreased. Serum ADH l...

Diabetes insipidus is a polyuric syndrome characterized by a pathologic excretion of large amounts of urine with low osmolality. It can originate from a total or partial lack of antidiuretic hormone (ADH) production from the pituitary gland or from “resistance” of the collecting tubules of the kidney to the ADH. Acute monocytic leukemia infiltrates the central nervous system in up to 50% of cas...

Central diabetes insipidus (CDI), characterized by polyuria and polydipsia, is caused by deficiency of arginine vasopressin (AVP), an antidiuretic hormone which acts on V2 receptors in kidney to promote reabsorption of free water. CDI is classified into three subtypes; idiopathic, secondary and familial. A previous study suggests that infundibulo-neurohypophysitis might be an underlying cause o...