Oxytocin (OT), a hormone most commonly associated with labor and lactation, may have a wide variety of physiological and pathological functions, which makes OT and its receptor potential targets for drug therapy. In this review, we highlight the newly discovered metabolic role of OT in diabetes and its complication, such as diabetic osteopathy. OT may have positive metabolic effects; this is ba...

This study was designed to investigate the inhibitory effect of Gynura procumbens extract against carbohydrate digesting enzymes and its ability to ameliorate postprandial hyperglycemia in streptozotocin (STZ)-induced diabetic mice. G. procumbens extract showed prominent α-glucosidase and α-amylase inhibitory effects. The half-maximal inhibitory concentration (IC50) of G. procumbens extract aga...

considering the anti-diabetic potential of trigonella foenum-graecum (tfg) and its beneficial effect on aortic reactivity of diabetic rats, this study was conducted to evaluate the effect of its alcoholic seed extract on aortic reactivity and also figure out mechanisms including the role of adrenergic and angiotensinergic systems in streptozotocin-diabetic rats. male wistar rats were divided in...

In our previous study, we reported the renoprotective effect of Hachimi-jio-gan, a Chinese traditional prescription consisting of eight medicinal plants, and also reported the effect of Corni Fructus (Cornus officinalis SIEB. et ZUCC.), a component of Hachimi-jio-gan, on diabetic nephropathy using diabetic rats. In this study, we investigated the effects of morroniside isolated from Corni Fruct...

Oxidative stress has previously been shown to play a role in the pathogenesis of diabetes mellitus (DM) and its complications. In the present study, the effects of supplementation with dietary antioxidants, flaxseed and α-tocopherol were investigated in diabetic golden Syrian hamsters fed with a high-fat diet. Thirty-five golden Syrian hamsters were randomly divided into a control group (C) and...

This study was designed to investigate the inhibitory effects of Polyopes lancifolia extract (PLE) on α-glucosidase activity, α-amylase activitiy, and postprandial hyperglycemia in streptozotocin (STZ)-induced diabetic mice. The results of this study revealed a marked inhibitory effect of PLE on α-glucosidase and α-amylase activities. The IC50s of PLE against α-glucosidase and α-amylase were 0....

Background: Nigella sativa (N. sativa) seeds are used to treat diabetes mellitus in traditional medicine. Moreover, N. sativa oil has reduced the fasting blood glucose level in non-diabetic volunteers. Objective: The present study was undertaken to explore the possible anti-hyperglycemic effect of N. sativa oil in type II diabetic patients. Methods: A randomized clinical trial was conducted ...

background and objectives: medicinal plants are well documented for possessing antidiabetic or antihyperglycaemic potential. abroma augusta seems to have the same effect in treating diabetes mellitus. the      aim of the present experiment was to report the efficacy of the aqueous extract of the leaves of a. augusta on biochemical and histological abnormalities of alloxan-induced diabetic rabbi...

Aloe vera is used worldwide for several medical purposes as alternative medicine. The present study was aimed to evaluate the antidiabetic, antihyperlipidemic and antioxidative activity of aloe vera gel extract in diabetic and control rats. Forty male albino rats, weighing (95±5g) were divided into four groups; group 1: normal control, group 2: Diabetic control group (by Intraperitoneal injecti...