AIMS Serum cystatin C (CysC) has recently been shown to be associated with the incidence of type 2 diabetes mellitus (T2DM) and progression to the pre-diabetic state. The aim of this study was to explore the relationship between serum CysC and the risk of gestational diabetes mellitus (GDM) in Chinese pregnant women. METHODS This cross-sectional study consisted of 400 pregnant women including...

Background. About 10% of pregnancies are complicated by previously unknown impairment of glucose metabolism, which is defined as gestational diabetes. There are little data available on prevalence of thyroid disorders in patients affected by gestational diabetes, and about their postgestational thyroid function and autoimmunity. We therefore investigated pancreatic and thyroid autoimmunity in g...

Continuous intravenous insulin and dextrose infusions were used in managing various diabetic emergencies. Standard and constant rates of insulin and dextrose infusion resulted in satisfactory control of blood glucose concentrations during labour, after major surgery, and in patients recovering from ketoacidosis (average insulin infusion rates 1, 2, and 3 U/h respectively). Higher infusion rates...

OBJECTIVE To assess whether glycemic control, soluble fms-like tyrosine kinase 1 (sFlt1) and placental growth factor (PlGF) were associated with the development of preeclampsia (PE) or gestational hypertension (GHTN) in women with preexisting diabetes. METHODS Maternal circulating angiogenic factors (sFlt1 and PlGF) measured on automated platform were studied at four time points during pregna...

AIMS Adiponectin is an adipokine that has anti-diabetic, anti-atherogenic, anti-inflammatory and angiogenic properties. This hormone has been implicated in both the physiological adaptation to normal pregnancy and in obstetrical complications. The aims of this study were to determine normal maternal plasma concentrations of adiponectin throughout gestation and to explore the relationships betwe...

Vitamin C (vitC) is essential for normal pregnancy and fetal development and poor vitC status has been related to complications of pregnancy. We have previously shown lower vitC status in diabetic women throughout pregnancy compared to that of non-diabetic controls. Here, we evaluate the relationship between vitC status late in diabetic pregnancy in relation to fetal outcome, complications of p...

Over a century ago Bennewitz (1828), when delivering a diabetic woman, observed that the giant foetus whose head had been born but whose shoulders were stuck fast 'seemed anxious and sighed with a clear voice'. In this depressed state the infant died, as so many of his kind have done since. Pregnancy complicating diabetes and the development of children born to diabetic women became problems on...

BACKGROUND AND OBJECTIVE Diabetes can complicate pregnancy but it is not the major complication of pregnancy. Though prevalence of diabetes is alarmingly high among Indians there have been very few studies assessing the effect of diabetes on pregnancy outcomes, particularly comparing pre-gestational diabetes mellitus [PGDM] and gestational diabetes [GDM] with non-diabetic mothers. METHODS Pre...

Before insulin therapy, the diabetic pregnancy was a consummate disaster for mother and child. Maternal mortality approached 30%, and survival of the offspring was uncommon (1). Although in 1988 diabetic mothers and their offspring clearly benefit from better perinatal care, many of the improvements shown to decrease maternal and perinatal morbidity have yet to be incorporated into the routine ...