Diabetic neuropathic pain is an important microvascular complication in diabetes mellitus and oxidative stress plays a vital role in associated neural and vascular complications. The present study investigated flavonoid rich fruit extract (ethyl acetate:methanol fraction) of E. officinalis (10 mg/kg), in type II diabetes (high fat diet fed/low dose streptozotocin) induced diabetic neuropathy in...

BACKGROUND Lower limb ulcers are a major source of morbidity and mortality in diabetic patients. Surgical coverage of these wounds is fraught with a high complication rate. Although clinically perforator flaps lead to good results in diabetic patients, there is little experimental data to support this finding. METHODS A total of 60 Wistar rats were randomly assigned either to the diabetic (n ...

Diabetic retinopathy is a common complication of diabetes. It represents one of the frequent causes of visual disability among diabetic subjects during the period of active life. The risk factors for diabetic retinopathy are poor glycemic control, hypertension, duration of diabetes, hyperlipidemia and proteinuria. It has been observed that prevalence of hypertension is higher in diabetic subjec...

angiotensin-converting enzyme (ace) inhibitors appear to correct many of the abnormalities associated with the vascular dysfunction found in diabetic patients. in this respect, quinapril is a unique ace inhibitor with multiple protective effects. the present study was carried out to investigate the effect of intraperitoneal administration of quinapril on the aortic reactivity of streptozotocin ...

Background: The most devastating manifestations of diabetes mellitus are vascular complications. Although there are many factors involved in the pathogenesis of diabetic vasculopathy, many studies suggest a role for glucose–induced oxidative stress. Studies in animal models, have demonstrated that the administration of antioxidants restores normal endothelial functions. The study was designed t...

The prevalence of diabetes mellitus continues to increase and is associated with significant morbidity mortality. To inform prevention strategies reduce the burden its related complications, we aimed investigate trends diabetic vascular complications-related deaths in United States. We obtained 20 years mortality data for US adults aged 18 older from National Vital Statistics System (NVSS), mul...

Diabetic neuropathy is a common complication of diabetes. The objective our study to evaluate the prevalence diabetic via DN4 questionnaire in patients and identify factors associated with neuropathy. We included 231 patients. average age was 45.77 years, 67.1% women, 36.8% type 1 63.2% 2 diabetic, duration diabetes evolution 7, 21 years old. HbA1c 10.4%. 28.1%, it more frequent unbalanced pati...