The distribution of the neuronal nicotinic acetylcholine receptor subunit alpha4 (nAChRalpha4) in the brains of young (2-4 months) or aged (24-28 months) CBA/J mice was examined using immunohistochemical staining. Anti-nAChRalpha4 immunoreactivity corresponded with nAChRalpha4 RNA expression and high-affinity [3H]nicotine binding. Immunostaining in aged mice relative to that in young animals wa...

Following injections of wheat germ agglutinin-conjugated horseradish peroxidase (WGA-HRP) or the fluorescent tracer fluoro-gold into the magnocellular preoptic area and the horizontal limb of the diagonal band, retrogradely labelled neurons were found in the homotopic region of the contralateral basal forebrain. Labelled fibers apparently arising from these neurons travelled in the stria medull...

Neurogenesis in the magnocellular basal telencephalic nuclei of the rat was examined with [(3)H]thymidine autoradiography. The experimental animals were the offspring of pregnant females given two injections of [(3)H]thymidine on consecutive embryonic (E) days (E12-E13, E13-E14, … E21-E22). On postnatal day (P) 60, the percentage of labeled cells and the proportion of cells originating during 2...

Spontaneous activity is an important characteristic of the principal cells in the main olfactory bulb (MOB) for encoding odor information, which is modulated by the basal forebrain. Cholinergic activation has been reported to inhibit all major neuron types in the MOB. In this study, the effect of diagonal band (NDB) stimulation on mitral/tufted (M/T) cell spontaneous activity was examined in an...

and controls, respectively). Unbiased stereologic analysis (3) and our own previous studies show that this region contains 6000 to 8000 cholinergic neurons in adult rats. The septal/diagonal band complex of mice is smaller than that in rats, and it is clear from brain sections that mice have about half the cholinergic neu-rons per section of equal thickness as do rats. Our numbers and those rep...

Behavioral, anatomical, and gene expression studies have shown functional dissociations between the dorsal and ventral hippocampus with regard to their involvement in spatial cognition, emotion, and stress. In this study we examined the difference of the multisynaptic inputs to the dorsal and ventral dentate gyrus (DG) in the rat by using retrograde trans-synaptic tracing of recombinant rabies ...

Adult neonatally gamma-irradiated rats were compared with control animals in a non-spatial olfactory associative task using two different procedures. Irradiation induced a clear reduction in the total mean area of the olfactory bulbs and hippocampus but not of the orbital prefrontal cortex, diagonal band and cell layers of the entorhinal and piriform cortex. The gamma-irradiation affected the g...

This paper presents the design, simulation, and measurement of two low-cost broadband circularly polarized (CP) printed antennas: a single element and an array at C band. The proposed single element antenna is excited by an L-shaped strip with a tapered end, located along the circular-slot diagonal line in the back plane. From the array experimental results, the 3 dB axial ratio bandwidth can r...

Aged rats (22 to 24 months) and young control rats (3 months) were tested in a battery of behavioral tests which included tests of learning, place navigation, sensorimotor integration, motor coordination, activity, and exploration. Following testing all animals were analyzed in an unanesthetized state for their local glucose utilization. Significant differences in glucose utilization were found...

BACKGROUND Nourishing "Yin"-Removing "Fire" Chinese Herb Mixture, a traditional herb-based formulation, has been successfully used for the management of idiopathic true precocious puberty (IPP) for more than thirty years. Precocious puberty rat model by neonatal administration of Danazol was used to investigate the effects of the herb mixture on the advanced sexual development of the rats, and ...