Domestic microwave ovens as well as laboratory reactors have been successfully employed to prepare dialkyl 1,4-dihydropyridine-3,5-dicarboxylates and to induce the synthesis of the corresponding aromatic derivatives. In that latter particular case, unexpected results have been reported.

Three-component reaction of dialkyl acetylenedicarboxylates, isocyanides and 1,3- diimino isoindoline affords highly functionalized 2,6-dihydropyrimido[2,1-a]isoindole derivatives in good yields under catalyst free and mild reaction conditions.

The Front Cover shows the one-pot procedure for introduction of aminoalkyl chain through dialkyl carbonate chemistry into different phenolic substrates. This green approach is a direct alcohol substitution that avoids use chlorine giving CO2 and ethanol as only reaction by-products. proposed has numerous potential applications N,N-dialkyl ethylamine moieties are incorporated in many pharmacopho...

0 We would like to thank Gurdip Bakshi, Nikunj Kapadia and Robert Tompkins for kindly sharing their data sets. We also thank seminar participants at Stanford University and Steve Figlewski for comments on a previous version of this paper. The second author is supported by an Advanced Fellowship from the EPSRC. The third author acknowledges partial financial support from DAAD, EPSRC and KWI.

*Department of Computer Science and Engineering, Indian Institute of Technology, DeLhi, New Delhi 110016, India. Work done while visiting Unlversit~/t Ulm. Supported in part by an Alexander von Humboldt postdoctoral research fellowship. IDepartment of Computer Science, University of Rochester, Rochester, NY 14627, USA. Supported in part by the National Science Foundation under research grant CC...

Introduction Patients with psoriasis are at risk of depression, anxiety and adjustment disorder (DAAD). Randomized control trials reported improvement in depression symptoms among patients receiving tumour necrosis factor inhibitors ustekinumab (TNFi/UST) versus placebo conventional systemic agents (CSA). The DAAD TNFi/UST CSA users was not assessed real-world settings. Objective To compare inc...

Some dialkyl alkylphosphonates and dialkyl phenylphosphonates were synthesized by the reactions between trialkyl phosphite and alkyl/aryl halide in the presence of benzene. The synthesized compounds were characterized by elemental analysis, thin layer chromatography (TLC), fourier –transform infrared, ( 1 H, 13 C) nuclear magnetic resonance (NMR) spectroscopic techniques. In vitro fungicidal ac...