29 Although the distribution of average fetal pulmonary trunk (PT) blood flow favors the ductus 30 arteriosus (DA) over the lungs, the phasic aspects of this distribution during systole and 31 diastole are not well understood. Accordingly, flow profile and wave intensity (WI) analyses 32 were performed at baseline and during brief flow increases accompanying an extrasystole 33 (ES) in ten anest...

Left ventricular filling dynamics were examined at rest and during supine bicycle exercise in 33 patients at cardiac catheterization; 23 had coronary artery disease (ischemia group), five with prior infarction had an akinetic area at rest (scar group), and five had minimal cardiovascular disease (control). Peak filling rate and mean filling rate during the first half and second half of diastole...

To estimate the effects of diltiazem on the left ventricular diastolic abnormalities in patients with hypertrophic cardiomyopathy, transmitral flow velocity during diastole was studied before and immediately after dynamic leg exercise with the pulsed Doppler technique combined with two-dimensional echocardiography. Seventeen patients with hypertrophic cardiomyopathy and 24 apparently healthy me...

The assumed rheological behavior of blood influences the hemodynamic characteristics numerical flow simulations. Until now, alternative specifications have been utilized, with uncertain implications for results obtained. This work aims to group sixteen models in homogeneous clusters, by exploiting data generated from simulations on an idealized symmetrical arterial bifurcation. Blood is be puls...

Left ventricular relaxation is dependent on afterload conditions during systole. An abrupt increase in afterload while the ventricle is actively contracting prolongs the duration of systole. An increase in afterload during ventricular relaxation shortens the duration of systole. Therefore, we hypothesized that the point during systole when an abrupt increase in afterload had no effect on the du...

Myocardial diastolic stiffness has been variably attributed to extracellular matrix composition, cytoskeletal properties of cardiomyocytes, or residual diastolic crossbridge cycling because of incomplete relaxation or cytosolic calcium removal.1 Extracellular matrix and cardiomyocyte cytoskeleton are presumed to mediate chronic rises in myocardial diastolic stiffness, as occur during aging, pre...