The primary purpose of this chapter is to provide public health officials, physicians, toxicologists, and other interested individuals and groups with an overall perspective of the toxicology of dichlorvos. It contains descriptions and evaluations of toxicological studies and epidemiological investigations and provides conclusions, where possible, on the relevance of toxicity and toxicokinetic ...

We describe here the purification and identification of a previously unrecognized target for organophosphorus compounds. The target, acylpeptide hydrolase, was isolated as a tritiated-diisopropylfluorophosphate-reactive protein from porcine brain and purified to homogeneity using a combination of ion-exchange and gel-filtration chromatography. Biochemical characterization and internal sequence ...

Cimex lectularius L. is a widespread hematophagus insect pest around the world and is currently experiencing a reemergence as a public health pest of concern. One possible source of bed bugs to the human environment is the movement of bed bugs from poultry facilities to human structures by poultry workers. No recent studies have been conducted on the susceptibility of this insect to a wide rang...

In mud houses in Wakara, Upper Volta, dichlorvos dispensers installed at the rate of one dispenser per approximately 500 cubic feet (14 m(3)) produced 70% or higher average kills of adult Aëdes aegypti, exposed overnight in screen wire cages suspended at levels of 6 feet (1.8 m) and 2 feet (0.6 m), for approximately three months during the wet season and four months during the dry season. Avera...

Organophosphate (OP) pesticides, monocrotophos (MCP), dichlorvos (DDVP) and phosphamidon significantly inhibit both MAO-A and MAO-B activities in rat brain mitochondria. The inhibition of MAO-A by MCP is reversible whereas the inhibition by DDVP and phosphamidon is irreversible. MAO-B is inhibited irreversibly by all these organophosphates suggesting that the mechanism of action of OP pesticide...

Pesticide Action Network, United Farmworkers of America, and California Rural Legal Assistance Foundation analyzed California government data on agricultural poisonings and enforcement of worker safety standards. Nearly 500 pesticide poisonings were reported for California farmworkers every year from 1997 to 2000. The actual number of pesticide-related illnesses is unknown, since many poisoning...