Our goal is to perform in-vitro biotransformation of Prodrugs of ibuprofen+paracetamol, diclofenac sodium+paracetamol and ibuprofen+diclofenac sodium by acidic and alkaline hydrolysis of both ester (–COO–) and amide (–CONH–) linkages into free drugs and chromatographically separation of their Rt in HPLC. Since both ester (–COO–) and amide (–CONH–) linkages are susceptible to hydrolysis in both ...

OBJECTIVE To evaluate the analgesic efficacy and safety of intramuscular drotaverine hydrochloride vs diclofenac sodium in treatment of acute renal colic. METHODS We conducted a randomized, single-blind study comparing single intramuscular doses of drotaverine hydrochloride (80 mg) vs diclofenac sodium (75 mg) on 100 patients (50 in each arm) presenting to the emergency department (ED) with r...

Aims—To evaluate the analgesic eVect of topical sodium diclofenac 0.1% during retinal laser photocoagulation. Methods—87 patients, 45 with proliferative diabetic retinopathy treated with two sessions of panretinal photocoagulation (group A), and 42 patients with nonproliferative diabetic retinopathy who underwent grid treatment of the posterior pole (19 bilaterally) (group B). Sodium diclofenac...

Diclofenac sodium was extensively used for treating arthritis, osteoarthritis and skeletal muscular injuries, which ultimately caused troubles aquatic organisms as well human beings. In this study, homogeneous catalytic advanced oxidation processes, including Fe2+/persulfate, Fe2+/peroxymonosulfate Fe2+/H2O2, were the degradation of diclofenac in water, without using UV-C light. About 89, 82 54...

Liposomes are the most advance formulation for targeting and controlled drug delivery system. These liposomes generally administered by intra-venous route. In this work liposome was prepared using thin film hydration method. The formulated is evaluated or characterised zeta sizer, Encapsulation efficiency, Entrapment vitro release. Main things which used of Diclofenac sodium, it having anti-inf...

The aim of this in vivo study was to assess the ability of the prodrug conjugate diclofenac-β-cyclodextrin to release diclofenac in the colon following oral administration, using sulfapyridine (a metabolite of sulfasalazine) as a marker of colonic absorption. Two groups of rats were used; the test rats received a suspension containing the two prodrugs, diclofenac-β-cyclodextrin and sulfasalazin...

PURPOSE To compare the corneal analgesic efficacy of the nonsteroidal anti-inflammatory drugs (NSAIDs) nepafenac, diclofenac, and ketorolac, and to evaluate the possibility that their inhibitory effects on corneal polymodal nociceptor fiber activity are partly mediated by a decrease in sodium currents. METHODS Corneal sensory afferent units were recorded in the anesthetized cat. The response ...

Carboxymethyl sago pulp (CMSP) with a degree of substitution 0.8 was synthesised from waste and cross-linked chitosan to form hydrogel by electron beam (EB) irradiation. Diclofenac sodium loaded into 40% CMSP/3% solution mixture irradiated at 25 kGy. The exhibited pH temperature-sensitive swelling behaviour. Fourier-transform infrared spectroscopy, field emission scanning microscope, X-ray diff...