The click chemistry era has generated a library of versatile "spring-loaded" reactions that offer high yields, regio- and stereospecificity, and outstanding functional group tolerance. These powerful transformations are particularly advantageous for the design of sophisticated biomaterials that require high levels of precision and control, namely, materials that promote tissue regeneration such...

The syntheses and biosyntheses of the paraherquamide and brevianamide families of prenylated indole-derived alkaloids are reviewed. It has been proposed that the unique bicyclo[2.2.2]diazaoctan ring system that is common to this family of natural products, arises by a biological intramolecular Diels-Alder cycloaddition reaction. Both synthetic approaches and total syntheses of several members o...

The fundamental aspects of chemical reaction kinetics at near-critical conditions are discussed within the framework of transition state theory and the thermodynamics of critical phenomena for multicomponent systems. This discussion emphasizes the geometric analysis of Griffiths and Wheeler which describes the manner in which various thermodynamic properties behave on approaching mixture critic...

Gold-catalyzed intermolecular reaction leading to dihydronaphthalene derivatives in one pot from two equivalents of ynones with respect styrene is uncovered. The [4+2] Diels–Alder cycloaddition and styrenes catalyzed by a mono-gold(I) complex the conjugated acid provide an unstable 3,8a-dihydronaphthalene subsequently undergo ene-type ?-activated ynone afford multi-component coupling products. ...

An eight-step linear sequence for the preparation of two diastereomers an 8-fluoro-ABC-steroid building block was developed. Key step intramolecular Diels–Alder reaction intermediate o-quinodimethane formed from a benzocyclobutene substituted with 5-fluorohex-5-en-4-one chain. This side chain prepared 6-chlorohex-1-ene by bromofluorination, elimination HBr, Finkelstein and alkylation literature...