We previously found that inhibition of the TCA cycle, either through mutations or chemical inhibition, increased toxT transcription in Vibrio cholerae. In this study, we found that the addition of malonate, an inhibitor of succinate dehydrogenase (SDH), decreased toxT transcription in V. cholerae, an observation inconsistent with the previous pattern observed. Unlike another SDH inhibitor, 2-th...

The regioselectivity of malonate addition to (3-methylpentadienyl)Fe(CO)3+ is controlled by the malonate-counterion association. The Li+ salt of malonate proceeds via C1 nucleophilic attack to afford the 1,3Z-diene complex 4a, while reaction of highly dissociated ion pair (i.e., Na+ or Li+/12-crown-4) salt proceeds at the C2 internal carbon to eventually afford cyclohexenone products 6. Reactio...

The inhibition of succinate oxidation by malonate is a well known phenomenon. Since the oxidation of succinate to fumarate is an integral part of the Krebs cycle of oxidations, it has been generally assumed that the inhibitory effect of malonate upon the oxidation of any member of the cycle is the result of the inhibition of the succinate to fumarate step. However, the present paper provides ev...

Among the factors involved in the accumulation of citrate by a tissue following the injection of fluoroacetate in viva is the ability of the tissue to convert precursors into 4-carbon acids (1). An indirect measure of the importance of this conversion was reported in a recent study (2) in which the Krebs cycle was blocked both by fluoroacetate and malonate, but in this study concurrent analyses...

Malonate has long been regarded as a specific inhibitor for succinic dehydrogenase. The original evidence was obtained in Thunberg experiments with resting bacterial cultures (1, 2), and similar results were later obtained manometrically with brain and muscle tissue (3). The apparent specificity of this inhibition has led workers to use respiration experiments with malonate as a basis for theor...

It was previously shown that oxygen uptake per mole of substrate, using resting cell suspensions of a strain of Pseudomonas fluorescens, was significantly higher on malonate than on acetate (Wolfe and Rittenberg, 1953). If malonate is anaerobically decarboxylated to carbon dioxide and acetate, one would expect comparable oxygen consumption on the two substrates. The observed difference in uptak...

Previously, we have reported that intranigral infusions of malonate, an inhibitor of mitochondrial function, lead to the degeneration of the dopaminergic neurons of the nigrostriatal pathway that is mediated, at least in part, through NMDA receptor activation and nitric oxide formation. In the present study, unilateral focal infusions of malonate into the nucleus basalis magnocellularis (nbM) o...

The title compound, [Dy(2)(C(3)H(2)O(4))(3)(H(2)O)(6)](n), forms a coordination polymeric structure comprising hydrated dysprosium ions and malonate ligands. In the asymmetric unit, there are one dysprosium ion, one and a half malonate ligands, and three water mol-ecules. Each Dy(III) atom is coordinated by six O atoms from four malonate ligands and by three water mol-ecules, and displays a tri...

Interest in malonic acid has been largely directed towards its role as a competitive inhibitor of succinic dehydrogenase. Very little attention has been directed toward the occurrence of malonic acid in plants or toward the metabolismi of malonic acid per se. Bentley ( 1 ) recently showed malonate to be present in some 18 species of legumes, one of which had concentrations as high as 2 mg/g dry...