Ion mobility spectrometry was used to monitor the degradation of phthalate vapors by corona discharge. Three different phthalates (dimethyl [DMP], diethyl [DEP], and dipropyl [DPP]) were examined in a discharge reactor (wire-to-cylinder geometry) at direct current positive polarity ambient air. The relative removal efficiencies up 96% energetical 229.27, 216.12, 198.84 kJ mg−1 achieved for DMP,...

Monolithic silica spin column extraction (MonoSpin-SPE) was developed as a simple, sensitive, and eco-friendly pretreatment method which combined with ultra-fast liquid chromatography-mass spectrometry (UFLC-MS) to determine the levels of six phthalate esters, dimethyl-(DMP), diethyl-(DEP), dipropyl- [DPrP], butyl-benzyl-(BBP), dicyclohexyl(DcHP), and di- n-octyl-(DOP) phthalate in physiologica...

BACKGROUND Limited data are available to assess human exposure to thousands of chemicals currently in commerce. Information that relates human intake of a chemical to its production and use can help inform understanding of mechanisms and pathways that control exposure and support efforts to protect public health. OBJECTIVES We introduce the intake-to-production ratio (IPR) as an economy-wide ...

Challenges in cumulative risk assessment of anti-androgenic phthalate mixtures include a lack of data on all the individual phthalates and difficulty determining the biological relevance of reduction in fetal testosterone (T) on postnatal development. The objectives of the current study were 2-fold: (1) to test whether a mixture model of dose addition based on the fetal T production data of ind...

In mammals, exposure to antiandrogenic chemicals during sexual differentiation can produce malformations of the reproductive tract. Perinatal administration of AR antagonists like vinclozolin and procymidone or chemicals like di(2-ethylhexyl) phthalate (DEHP) that inhibit fetal testicular testosterone production demasculinize the males such that they display reduced anogenital distance (AGD), r...

Phthalate esters, alkylphenols, bisphenol A and their chlorinated derivatives are the suspected endocrine disrupters or mutagens. These compounds, commonly called endocrine disrupter chemicals (EDCs), are widely used as plastic additives, lacquers, resins, or surfactants and can be usually found in environmental samples, namely wastewaters. An accurate and reproducible gas chromatographic-mass ...

Plasticizers are commonly added to poly(vinyl chloride) (PVC) and other brittle polymers to improve their flexibility and processing properties. Phthalate plasticizers such as di(2-ethylhexyl phthalate) (DEHP) are the most common PVC plasticizers and have recently been linked to a wide range of developmental and reproductive toxicities in mammals. Our group has developed several replacement com...

Pure organic substances are the first and key link in chain of metrological traceability analysis. In most cases, purity determination substance is a non-trivial task, solution which requires preliminary theoretical study understanding capabilities instrumental methods for developing pertinent analytical procedure. Within study, an algorithm determining separate group compounds – ortho-phthalic...