نتایج جستجو برای: dihydrotestosterone
تعداد نتایج: 2392 فیلتر نتایج به سال:
Mouse CYP2J5 is abundant in kidney and active in the metabolism of arachidonic acid to epoxyeicosatrienoic acids. Western blots of microsomes prepared from mouse kidneys demonstrate that after puberty, CYP2J5 protein is present at higher levels in male mice than in female mice. Northern analysis reveals that CYP2J5 transcripts are more abundant in adult male versus female kidneys, indicating th...
A technically simple route is described to individual epimers of side-chain derivatives of lanosterol (3beta-hydroxy-5alpha-lanosta-8,24-diene). Epimerically pure 24,25-epoxy-, 24,25-dihydroxy- and 24-bromo-25-hydroxy-lanosterol have been prepared in good yield from commercial (50-60%) lanosterol. Hypophosphorous acid was used as a catalyst for the cohalogenation of the Delta24(25) bond and als...
<p>Nickel nanoparticles (NiNPs) have toxic effects on body cells due to the production of free radicals. The purpose this research was investigate protective Gallic acid (GA) and Curcumin (Cur) hepatic transaminases, blood plasma parameters pituitary-testicular hormones levels in NiNPs-treated rats. Seventy adult male Wistar rats were divided 7 groups 10 including control, Ni50 mg/kg, Ni5...
Background and Objective: The pit of Phoenix dactylifera contains different chemical compounds such as saturated and unsaturated fatty acids, Zinc(Zn), Cadmium(Cd), Calcium(Ca), and potassium(K). Saturated fatty acids include stearic and palmitic acid and unsaturated fatty acids contain linoleic and oleic acids which could inhibit 5- - reductase enzyme. The present study was carried out with th...
A potential PET imagining agent for prostate and prostate derived tumors, N-3-[18F]fluoropropylputrescine, has been prepared. The radiochemical yield was 7-10% at end-of-synthesis (EOS) and the specific activity was greater than 1.1 Ci/mumol (overall synthesis time was 1.5 hr). In vivo biodistribution in mature male rats showed high prostate uptake. In rats that were pretreated with alpha-diflu...
Steroid 5AR converts testosterone to dihydrotestosterone; steroid aromatase converts testosterone to oestradiol in males and females (androgen deprivation results in oestrogen deprivation). Oestradiol, the product of testosterone aromatization, binds to the androgen and oestrogen receptors. Dihydrotestosterone (DHT) mediates cellular apoptosis through the paracrine prostate stromal cell factors...
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